1027189-58-7Relevant academic research and scientific papers
Hypoglycemic activity of a series of α-alkylthio and α-alkoxy carboxylic acids related to ciglitazone
Hulin, Bernard,Newton, Linda S.,Lewis, Diana M.,Genereux, Paul E.,Gibbs, E. Michael,Clark, David A.
, p. 3897 - 3907 (2007/10/03)
The thiazolidinedione moiety of ciglitazone and its analogues can be replaced by an α-alkoxy or α-thioether carboxylic acid group. The influence of the nature of the R group, the length of the connector to the aromatic backbone of the molecule, and the stereochemistry have been studied. The most potent compounds have glucose-lowering activity at doses as low as 0.01 mg/kg.
