1027223-93-3Relevant academic research and scientific papers
Pourbaix diagrams in weakly coupled systems: A case study involving acridinol and phenanthridinol pseudobases
Walpita, Janitha,Yang, Xin,Khatmullin, Renat,Luk, Hoi Ling,Hadad, Christopher M.,Glusac, Ksenija D.
, p. 204 - 208 (2016)
The thermodynamics of proton-coupled electron transfer (PCET) in weakly coupled organic pseudobases was investigated using 2,7-dimethyl-9-hydroxy-9-phenyl-10-tolyl-9,10-dihydroacridine (AcrOH) and 6-phenylphenanthridinol (PheOH) as model compounds. Pourba
Synthesis of Stannylated Aryl Imines and Amines via Aryne Insertion Reactions into Sn?N Bonds
Kran, Eva,Mück-Lichtenfeld, Christian,Daniliuc, Constantin G.,Studer, Armido
, p. 9281 - 9285 (2021/05/31)
The reaction of in situ generated arynes with stannylated imines to provide ortho-stannyl-aniline derivatives is reported. The readily prepared trimethylstannyl benzophenone imine is introduced as an efficient reagent to realize the aryne σ-insertion reaction. The imine functionality is an established N-protecting group and insertions proceed with good yields and good to excellent regioselectivities. The product anilines are valuable starting materials for follow-up chemistry thanks to the rich chemistry offered by the trimethylstannyl moiety.
Scaffold-divergent synthesis of ring-fused indoles, quinolines, and quinolones via iodonium-induced reaction cascades
Halim, Rosliana,Aurelio, Luigi,Scammells, Peter J.,Flynn, Bernard L.
, p. 4708 - 4718 (2013/06/27)
N-(2-Iodophenyl)imines A are readily formed from Schiff's base condensation of 2-iodoanilines with carbonyls and ketals. These imines provide useful substrates in scaffold-divergent synthesis through the attachment of an alkyne (Songashira coupling or acyl substitution of a Weinreb amide) followed by an iodonium-induced reaction cascade to give ring-fused indoles B, quinolines C, or quinolones D depending on the reaction conditions employed.
PYRROLOQUINOLINE ALKALOIDS AS ANTIMALARIAL AGENTS AND PROCESS FOR THE PREPARATION THEREOF
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Page/Page column 19; 21; 23, (2013/08/28)
The patent provides novel compounds with potential anti-malarial activity and process of synthesis thereof. Further, the process for the synthesis of known antimalarial natural products marinoquinazolinone A-F, aplidiopsamine A and their potential antimal
Pd-catalyzed imine cyclization: Synthesis of antimalarial natural products aplidiopsamine A, marinoquinoline A, and their potential hybrid nclite-M1
Mahajan, Jyoti P.,Suryawanshi, Yogeshwar R.,Mhaske, Santosh B.
supporting information, p. 5804 - 5807 (2013/01/15)
Palladium-catalyzed cyclization of imines has been developed to construct the extremely rare 3H-pyrrolo[2,3-c]quinoline ring system for diversity oriented first total synthesis of antimalarial marine natural product Aplidiopsamine A as well as synthesis o
Alternating lodonium-mediated reaction cascades giving indole- And quinoline-containing polycycles
Halim, Rosliana,Scammells, Peter J.,Flynn, Bernard L.
supporting information; experimental part, p. 1967 - 1970 (2009/04/10)
A simple two-step convergent protocol gives direct access to synthetic Intermediate A from ortho-iodoanilines. Intermediate A can be treated with NIS In CH2CI2 to Induce novel lodonium mediated domino reaction cascade, which provides direct access to ring-fused Indole compounds B. Simply by changing the reaction conditions, this protocol can be directed down an alternative domino reaction cascade to give various ring fused quinoline compounds C.
