1027271-96-0Relevant academic research and scientific papers
Synthesis and application of α-trifluoromethylated aldehydes
Konno,Yamazaki,Kitazume
, p. 199 - 208 (2007/10/02)
Two methods for the synthesis of α-trifluoromethylated aldehydes are described. One is a synthetic method via Pummerer rearrangement followed by the hydrolysis under the weakly basic condition, giving the racemic aldehyde. The other is via the oxidative cleavage of the corresponding diol under the acidic condition, affording the optically active compound for the first time. Furthermore, both aldehydes underwent the reaction with some nucleophiles in good yields.
Highly Stereoselective Asymmetric Michael Addition Reactions Employing (R;E)-3,3,3-Trifluoroprop-1-enyl p-Tolyl Sulphoxide
Yamazaki, Takashi,Ishikawa, Nobuo,Iwatsubo, Hitoshi,Kitazume, Tomoya
, p. 1340 - 1342 (2007/10/02)
(R;E)-3,3,3-Trifluoroprop-1-enyl p-tolyl sulphoxide, prepared in three steps from ethyl trifluoroacetate, showed a high degree of diastereoselectivity in Michael addition reactions with enolates; by this means, optically active trifluoromethylated organic molecules can be obtained readily in high yield as well as in high optical purity.
