200629-01-2

Upstream product

• 113965-67-6 (R;E)-3,3,3-trifluoroprop-1-enyl p-tolyl sulphoxide 
• 113965-74-5 (3R,R_S)-ethyl 3-(trifluoromethyl)-4-(4-methylphenylsulfinyl)butanoate 
• 106-45-6 para-thiocresol 
• 100-39-0 benzyl bromide 
• 1027271-96-0 (R)-4,4,4-Trifluoro-3-p-tolylsulfanylmethyl-butan-1-ol 

Downstream Products

• 173975-01-4 4-Benzyloxy-2-trifluoromethyl-butyraldehyde 

Relevant academic research and scientific papers

Stereoselective synthesis of trifluoromethylated compounds via Johnson-Claisen and Eshenmoser-Claisen rearrangements

Johnson-Claisen and Eshenmoser-Claisen rearrangements of chiral γ-trifluoromethylated allylic alcohols, which were prepared via effective enzymatic resolution of the corresponding propargylic alcohols, are demonstrated. As a result, it is shown that both

Synthesis and application of α-trifluoromethylated aldehydes

Two methods for the synthesis of α-trifluoromethylated aldehydes are described. One is a synthetic method via Pummerer rearrangement followed by the hydrolysis under the weakly basic condition, giving the racemic aldehyde. The other is via the oxidative cleavage of the corresponding diol under the acidic condition, affording the optically active compound for the first time. Furthermore, both aldehydes underwent the reaction with some nucleophiles in good yields.