1027282-15-0Relevant academic research and scientific papers
Facile synthesis of novel spiro[azetidine-2,4'(1H)-isoquinoline-1',3',4(2'H)-triones]
Malamas
, p. 565 - 568 (2007/10/02)
A convenient general method for the synthesis of a new heterocycle, spiro[azetidine-2,4'(1'H)-isoquinoline-1',3',4(2'H)-trione] is described. The key intermediate 2 was prepared by direct halogenation of position-4 of acid 3 with thionyl chloride, and sub
N-substituted spirosuccinimide, spiropyridazine, spiroazetidine, and acetic acid aldose reductase inhibitors derived from isoquinoline-1,3- diones. 2
Malamas,Hohman
, p. 2059 - 2070 (2007/10/02)
The isoquinoline-1,3-dione framework featured in our clinical candidate (1) and its congener was used as the template in the design of several new series of aldose reductase inhibitors (ARIs). These series included N'- substituted spirosuccinimide, spirop
