1027301-67-2Relevant academic research and scientific papers
(E)-1-Heterocyclyl or cyclohexyl)-2- ethenes as A2a adenosine receptor antagonists
Giudice, M. R. Del,Borioni, A.,Mustazza, C.,Gatta, F.,Dionisotti, S.,et al.
, p. 59 - 64 (1996)
Some 1,3,7-trisubstituted-8-styrylxanthine analogues, with the aryl group replaced by a heterocycle or cyclohexane ring, were prepared and evaluated for their interaction with the A1 and A2a adenosine receptors.The highest degree of activity was displayed by the 1,3-dipropyl-7-methyl-8-xanthine 4cdi, which was found to be a potent and selective A2a antagonist in binding assays (Ki = 19 nM, A1/A2a ratio = 30). - Keywords: 8-styrylxanthine analogue; adenosine A2a receptor antagonist
