European Journal of Medicinal Chemistry p. 59 - 64 (1996)
Update date:2022-08-03
Topics:
Giudice, M. R. Del
Borioni, A.
Mustazza, C.
Gatta, F.
Dionisotti, S.
et al.
Some 1,3,7-trisubstituted-8-styrylxanthine analogues, with the aryl group replaced by a heterocycle or cyclohexane ring, were prepared and evaluated for their interaction with the A1 and A2a adenosine receptors.The highest degree of activity was displayed by the 1,3-dipropyl-7-methyl-8-<2-(3-thienyl)ethenyl>xanthine 4cdi, which was found to be a potent and selective A2a antagonist in binding assays (Ki = 19 nM, A1/A2a ratio = 30). - Keywords: 8-styrylxanthine analogue; adenosine A2a receptor antagonist
View MoreHangzhou JINLAN Pharm-Drugs Technology Co., Ltd
website:http://www.jlpharms.com
Contact:86-571-86982636
Address:Rm A606, Fuyi Center, jianqiao street
SPRING CHEMICAL INDUSTRY CO.,LTD
Contact:86-187-66672125
Address:linchi industry park.zouping
Contact:86-25-58619180
Address:Nanjing High-Tech Zone 10 Xinghuo Road Pukou District Nanjing, Jiangsu 210061 The People's Republic of China
Hangzhou Sartort Biopharma Co., Ltd
website:http://www.sartort.com
Contact:86-571-87039693
Address:No. 57, Tech Park Road, Hangzhou, Zhejiang, China
Nanjing Chemlin Chemical Co., Ltd.
website:http://www.echemlin.cn
Contact:+86-25-83697070
Address:Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China
Doi:10.1021/ja7111417
(2008)Doi:10.1002/jhet.3969
(2020)Doi:10.1016/j.tetlet.2007.07.033
(2007)Doi:10.1021/jo01091a005
(1959)Doi:10.1021/jo01117a006
(1956)Doi:10.1080/10426500802391692
(2009)
