European Journal of Medicinal Chemistry p. 59 - 64 (1996)
Update date:2022-08-03
Topics:
Giudice, M. R. Del
Borioni, A.
Mustazza, C.
Gatta, F.
Dionisotti, S.
et al.
Some 1,3,7-trisubstituted-8-styrylxanthine analogues, with the aryl group replaced by a heterocycle or cyclohexane ring, were prepared and evaluated for their interaction with the A1 and A2a adenosine receptors.The highest degree of activity was displayed by the 1,3-dipropyl-7-methyl-8-<2-(3-thienyl)ethenyl>xanthine 4cdi, which was found to be a potent and selective A2a antagonist in binding assays (Ki = 19 nM, A1/A2a ratio = 30). - Keywords: 8-styrylxanthine analogue; adenosine A2a receptor antagonist
View MoreSichuan Sangao Biochemical Co., Ltd
Contact:+86-28-84874233
Address:19F, Bldg.2, Shudu Center, Tianfu 2nd St., Hi-tech zone, Chengdu 610041, Sichuan Province, China.
shanghai jinshan pharmaceutical Co.,Ltd
Contact:021-57363011，13681638167
Address:No. 7966 Tingfeng Road,Jinshan,Shanghai,China
Tianjin Tensing Fine Chemical Research Develop Centre
Contact:86-022-23718576,13032267585
Address:2-2-201,13 Guiyuan road,Huayuan Industry district,Tianjin,china
Chemvon Biotechnology Co. Ltd.
website:http://www.chemvon.com
Contact:86-21-58550039;86-21-31268550-8004
Address:Suite B-10#, 6999 Chuansha Road, Pudong District, Shanghai 201202, China
Weifang Dongxing Chitosan Factory
website:http://dxchitosan.lookchem.com/
Contact:13475651157
Address:Weifang city ,shandong province
Doi:10.1021/ja7111417
(2008)Doi:10.1002/jhet.3969
(2020)Doi:10.1016/j.tetlet.2007.07.033
(2007)Doi:10.1021/jo01091a005
(1959)Doi:10.1021/jo01117a006
(1956)Doi:10.1080/10426500802391692
(2009)
