102734-75-8Relevant academic research and scientific papers
Efficient Synthesis of 2-Amino-1-Arylethanols Through a Lewis Base-Catalyzed SiCl4-Mediated Asymmetric Passerini-Type Reaction
Ayad, Tahar,Gernet, Aurélie,Pirat, Jean-Luc,Ratovelomanana-Vidal, Virginie,Virieux, David
supporting information, p. 6497 - 6500 (2020/10/30)
We herein report, a practical and efficient strategy for the synthesis of enantiomerically enriched 2-amino-1-arylethanols, a structural motif commonly encountered in the family of β-adrenergic blockers or agonists, through a Lewis base-catalyzed SiClsub
ALKYLATION OF N-TRIMETHYLSILYLATED PRIMARY AMINES WITH ARYLETHYLENE OXIDES. AN EFFICIENT SYNTHESIS OF 1-PHENETHANOLAMINES.
Atkins, Randall K.,Frazier, Jeffery,Moore, Larry L.,Weigel, Leland O.
, p. 2451 - 2454 (2007/10/02)
Reaction of unhindered N-trimethylsilylated primary amines with styrene oxide derivatives provides good yields of 1-phenethanolamines after acidic hydrolysis during work-up.This methodology results in much better conversions and higher yields when compare
