1027340-25-5Relevant academic research and scientific papers
Stereocontrolled synthesis of glycosidase inhibitors (+)-hyacinthacines A1 and A2
Veyron, Ama?l,Reddy, Paidi Venkatram,Koos, Peter,Bayle, Alexandre,Greene, Andrew E.,Delair, Philippe
, p. 85 - 94 (2015/02/19)
(+)-Hyacinthacines A1 and A2 have been prepared from an easily available, advanced intermediate. The non-chiral pool approach features a dichloroketene-enol ether [2+2] cycloaddition and a dihydroxylation or epoxidation as key stereoselective transformations.
Approach to the hyacinthacines: First non-chiral pool synthesis of (+)-hyacinthacine A1
Reddy, P. Venkatram,Veyron, Amael,Koos, Peter,Bayle, Alexandre,Greene, Andrew E.,Delair, Philippe
scheme or table, p. 1170 - 1172 (2008/10/09)
The first non-chiral pool total synthesis of (+)-hyacinthacine A 1 is described. This synthesis is based on an effective [2 + 2] cycloaddition of dichloroketene to a Stericol-based enol ether, a diastereoselective dihydroxylation, and an efficient Tamao-Fleming oxidation. This journal is The Royal Society of Chemistry.
