1027345-23-8

Basic information

• Product Name: 7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4(3H)-one
• Synonyms: 7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4(3H)-one
• CAS NO: 1027345-23-8
• Molecular Weight: 430.937
• Mol File: 1027345-23-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4(3H)-one(1027345-23-8)
• EPA Substance Registry System: 7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4(3H)-one(1027345-23-8)

Safety Data

• Hazardous Substances Data: 1027345-23-8(Hazardous Substances Data)

Upstream product

• 4255-62-3 4,4-dimethylcyclohexane-1-one 
• 50388-51-7 methyl 5,5-dimethyl-2-oxo-cyclohexanecarboxylate 
• 1027345-19-2 methyl 5,5-dimethyl-2-(trifluoromethylsulfonyloxy)cyclohex-1-enecarboxylate 
• 1027345-20-5 methyl 2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enecarboxylate 
• 1027345-21-6 (4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methanol 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 1001754-57-9 2-bromomethyl-4'-chlorobiphenyl 
• 1027345-17-0 tert-butyl 4-(4-aminoquinazolin-7-yl)piperazine-1-carboxylate 
• 1027345-16-9 tert-butyl 4-(3-amino-4-cyanophenyl)piperazine-1-carboxylate 
• 1027345-32-9 2-amino-4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)benzonitrile 
• 1027345-31-8 4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)-2-nitrobenzonitrile tosylate 
• 1027345-29-4 4-(4-(2-bromobenzyl)piperazin-1-yl)-2-nitrobenzonitrile 
• 1027345-15-8 tert-butyl 4-(4-cyano-3-nitrophenyl)piperazine-1-carboxylate 
• 1027345-22-7 6-(bromomethyl)-4'-chloro-4,4-dimethyl-2,3,4,5-tetrahydro-1,1'-biphenyl 

Downstream Products

• 1027345-24-9 4-chloro-7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazoline 
• 1027344-89-3 N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-dimethylamino-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-nitrobenzenesulfonamide 
• 1027344-93-9 N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-(morpholin-4-yl)-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-nitrobenzenesulfonamide 
• 1027344-91-7 N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-dimethylamino-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-(trifluoromethanesulfonyl)benzenesulfonamide 
• 1027344-95-1 N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-(morpholin-4-yl)-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-(trifluoromethanesulfonyl)benzenesulfonamide 
• 1197199-79-3 N-(7-[4-fluorophenyl]quinazolin-4-yl)-4-((1-(phenylthio)ethan-2-yl)amino)-3-nitrobenzenesulfonamide 
• 1197199-73-7 N-(7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4-yl)-3-nitro-4-(2-(phenylthio)ethylamino)benzenesulfonamide 

Relevant articles and documents

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

ABT-737 and ABT-263 are potent inhibitors of the BH3 antiapoptotic proteins, Bcl-xL and Bcl-2. This class of putative anticancer agents invariantly contains an acylsulfonamide core. We have designed and synthesized a series of novel quinazoline-based inhibitors of Bcl-2 and Bcl-xL that contain a heterocyclic alternative to the acylsulfonamide. These compounds exhibit submicromolar, mechanism-based activity in human small-cell lung carcinoma cell lines in the presence of 10% human serum. This comprises the first successful demonstration of a quinazoline sulfonamide core serving as an effective benzoylsulfonamide bioisostere. Additionally, these novel quinazolines comprise only the second known class of Bcl-2 family protein inhibitors to induce mechanism-based cell death.

ARYLSULFONAMIDE COMPOUNDS

The invention relates generally to small molecules that mimic the biological activity of certain peptides and proteins, to compositions containing them and to their use. In particular, the invention relates to compounds of the general formula (I) that mim