7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4(3H)-one

Base Information

• Chemical Name: 7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4(3H)-one
• CAS No.: 1027345-23-8
• Molecular Formula: C₂₅H₂₃ClN₄O
• Molecular Weight: 430.937

Synonyms:7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4(3H)-one

Chemical Property of 7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4(3H)-one

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Technology Process of 7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4(3H)-one

There total 26 articles about 7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-amine (1027345-33-0) → 7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-ol (1027345-23-8)

Guidance literature:

With hydrogenchloride; acetic acid; In water; at 130 ℃; for 9h;

Reference yield: 87.0%

7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-amine (1027345-33-0) → 7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4(3H)-one (1027345-23-8)

Guidance literature:

7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-amine; With hydrogenchloride; water; acetic acid; at 130 ℃; for 9h;

With ammonia; In water;

Reference yield: 80.0%

2-bromomethyl-4'-chlorobiphenyl (1001754-57-9) + 2BrH*C12H14N4O → 7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4(3H)-one (1027345-23-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20.5h;

upstream raw materials:

2-bromomethyl-4'-chlorobiphenyl

7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-amine

tert-butyl 4-(4-cyano-3-nitrophenyl)piperazine-1-carboxylate

4-(4-(2-bromobenzyl)piperazin-1-yl)-2-nitrobenzonitrile

Downstream raw materials:

4-chloro-7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazoline

N-(7-[4-fluorophenyl]quinazolin-4-yl)-4-((1-(phenylthio)ethan-2-yl)amino)-3-nitrobenzenesulfonamide

N-(7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4-yl)-3-nitro-4-(2-(phenylthio)ethylamino)benzenesulfonamide

N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-dimethylamino-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-nitrobenzenesulfonamide

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