102735-84-2

Basic information

• Product Name: 5-CHLORO INDAZOLE-3-CARBOXALDEHYDE
• Synonyms: 5-CHLORO-3-(1H)INDAZOLE CARBOXALDEHYDE;5-CHLORO INDAZOLE-3-CARBOXALDEHYDE;5-Chloro-3-(1H)indazole;5-CHLORO-1H-INDAZOLE-3-CARBALDEHYDE;5-Chloro-1H-indazole-3-carbaldehyde ,97%;1H-Indazole-3-carboxaldehyde, 5-chloro-;5-chloro-2H-indazole-3-carbaldehyde
• CAS NO: 102735-84-2
• Molecular Formula: C8H5ClN2O
• Molecular Weight: 180.59
• EINECS: 1806241-263-5
• Product Categories: Indazole
• Mol File: 102735-84-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 391.695 °C at 760 mmHg
• Flash Point: 190.691 °C
• Appearance: /
• Density: 1.521 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.748
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.85±0.40(Predicted)
• CAS DataBase Reference: 5-CHLORO INDAZOLE-3-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO INDAZOLE-3-CARBOXALDEHYDE(102735-84-2)
• EPA Substance Registry System: 5-CHLORO INDAZOLE-3-CARBOXALDEHYDE(102735-84-2)

Safety Data

• Hazardous Substances Data: 102735-84-2(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1/C8H5ClN2O/c9-5-1-2-7-6(3-5)8(4-12)11-10-7/h1-4H,(H,10,11)

Upstream product

• 1079-46-5 methyl 5-chloro-1H-indazole-3-carboxylate 
• 17630-76-1 5-chloroindole 2,3-dione 
• 1077-95-8 5-chloro-1H-indazole-3-carboxylic acid 
• 102735-90-0 5-chloro-3-(hydroxymethyl)indazole 
• 754948-43-1 5-chloro-1H-indole 
• 17422-32-1 5-chloro-1H-indole 

Relevant articles and documents

An optimized procedure for direct access to 1: H -indazole-3-carboxaldehyde derivatives by nitrosation of indoles

Indazole derivatives are currently drawing more and more attention in medicinal chemistry as kinase inhibitors. 1H-indazole-3-carboxaldehydes are key intermediates to access to a variety of polyfunctionalized 3-substituted indazoles. We report here a general access to this motif, based on the nitrosation of indoles in a slightly acidic environment. These very mild conditions allow the conversion of both electron-rich and electron-deficient indoles into 1H-indazole-3-carboxaldehydes.

Indazole benzimidazole compounds

Organic compounds having the structure I are provided where the variables have the values described herein. Pharmaceutical formulations and medicaments include the organic compound or a pharmaceutically acceptable salt thereof and a pharmaceutically accep