1077-95-8

Basic information

• Product Name: 5-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID
• Synonyms: 5-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID;5-CHLORO-3-(1H)INDAZOLE CARBOXYLIC ACID;5-CHLORO-3-INDAZOLECARBOXYLIC ACID;5-CHLORO-3-INDOZOLE-CARBOXYLIC ACID;5-Chloro-1H-indazole-3-carboxylic acid ,97%;1H-Indazole-3-carboxylic acid, 5-chloro-;5-chloro-1H-indazol-3-carboxylic acid
• CAS NO: 1077-95-8
• Molecular Formula: C₈H₅ClN₂O₂
• Molecular Weight: 196.59
• Product Categories: pharmacetical;Indazole
• Mol File: 1077-95-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 337 °C
• Boiling Point: 472.131 °C at 760 mmHg
• Flash Point: 239.336 °C
• Appearance: /
• Density: 1.644 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.744
• Storage Temp.: 2-8°C
• PKA: 2.82±0.30(Predicted)
• CAS DataBase Reference: 5-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID(1077-95-8)
• EPA Substance Registry System: 5-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID(1077-95-8)

Safety Data

• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 1077-95-8(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1/C8H5ClN2O2/c9-4-1-2-6-5(3-4)7(8(12)13)11-10-6/h1-3H,(H,10,11)(H,12,13)

Upstream product

• 17630-76-1 5-chloroindole 2,3-dione 

Downstream Products

• 1079-46-5 methyl 5-chloro-1H-indazole-3-carboxylate 
• 102735-84-2 5-chloro-1H-indazole-3-carbaldehyde 
• 28751-70-4 5-chloro-1H-indazole-3-carboxamide 
• 29646-35-3 5-chloro-1H-indazole-3-carbonitrile 
• 1448314-59-7 5-chloro-1-(3-methylbenzoyl)-1H-indazole-3-carboxylic acid ethyl ester 

Relevant articles and documents

CARBOXYLIC ACID, ACYL SULFONAMIDE AND ACYL SULFAMIDE-DERIVATIZED BICYCLIC AZA-HETEROAROMATICS AS SELECTIVE MCL-1 INHIBITORS AND AS DUAL MCL-1/BCL-2 INHIBITORS

Mcl-1 selective inhibitors, Bcl-2 selective inhibitors, and Mcl-1/Bcl-2 dual inhibitors and methods of using the same for the treatment of disease are disclosed.

ANTICANCER AGENT

An anticancer agent comprising a compound represented by the formula (I) [R1 represents hydrogen atom, hydroxyl group, a C1-6alkoxy group and the like; R2 and R3 represents hydrogen atom, a halogen atom, a C1-6alkyl group and the like; R4 represents hydrogen atom, a C1-6alkyl group, a C1-6alkylsulfonyl group and the like; R5 represents hydrogen atom or a substituent; .... represents a single bond or a double bond; R6 and R7 represents hydrogen atom, a C1-6alkyl group and the like; R8 represents hydrogen atom, a C1-6alkyl group and the like; A represents -O-, -S-, or - CH2-; D represents -C= or -N=; X represents methylene group, -O-, or -CO-; Q represents -N= or -C(R8)=; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.

1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS MAPKAP KINASE MODULATORS

The invention provides compounds of the formula: (I) for use in the prophylaxis or treatment of a disease state or condition mediated by a MAPKAP kinase: wherein A is a bond or a group CH2; R1 is a carbocyclic or heterocyclic group having from 3 to 12 ring members; R3, R4, R5 and R6 are the same or different and are each selected from hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, carboxy, amino, carbocyclic and heterocyclic groups having from 3 to 12 ring members; a group Ra -Rbwherein Ra is a bond, 0, CO, X1C(X2), C(X2)Xl, X1C(X2)X1, S, SO, S02, NRc, SO2NRc or NRcS02; and Rb is selected from hydrogen, carbocyclic and heterocyclic groups having from 3 to 12 ring members, and a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from hydroxy, oxo, halogen, cyano, nitro, amino, mono or di-C1-4 hydrocarbylamino, carbocyclic and heterocyclic groups having from 3 to 12 ring members and wherein one or more carbon atoms of the C1-8 hydrocarbyl group may optionally be replaced by 0, S, SO, SO2, NRc, X1C(X2), C(X2)X1 or X1C(X2)X1; Rc is hydrogen or C1-4hydrocarbyl; and X1 is O, S or NRc and X2 is =O, =S or =NRc.