1027385-16-5

Basic information

• Product Name: 4-[(4,4-Dimethyl-9-oxo-3,4,6,7,8,9-hexahydro-2H-benzo[g]chromen-8-yl)-hydroxy-methyl]-benzoic acid methyl ester
• CAS NO: 1027385-16-5
• Molecular Weight: 394.467
• Mol File: 1027385-16-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[(4,4-Dimethyl-9-oxo-3,4,6,7,8,9-hexahydro-2H-benzo[g]chromen-8-yl)-hydroxy-methyl]-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(4,4-Dimethyl-9-oxo-3,4,6,7,8,9-hexahydro-2H-benzo[g]chromen-8-yl)-hydroxy-methyl]-benzoic acid methyl ester(1027385-16-5)
• EPA Substance Registry System: 4-[(4,4-Dimethyl-9-oxo-3,4,6,7,8,9-hexahydro-2H-benzo[g]chromen-8-yl)-hydroxy-methyl]-benzoic acid methyl ester(1027385-16-5)

Safety Data

• Hazardous Substances Data: 1027385-16-5(Hazardous Substances Data)

Upstream product

• 158303-16-3 3,4,5,6,7,8-hexahydro-5,5-dimethyl-8-oxo-1(2H)anthracenone 
• 1571-08-0 methyl 4-formylbenzoate 
• 158303-13-0 4-(4,4-Dimethyl-chroman-6-yl)-4-oxo-butyric acid ethyl ester 
• 158303-14-1 4-(4,4-Dimethyl-chroman-6-yl)-4-oxo-butyric acid 
• 1026619-07-7 4-(4,4-Dimethyl-chroman-6-yl)-butyryl chloride 
• 158303-15-2 4-(4,4-Dimethyl-chroman-6-yl)-butyric acid 
• 40614-27-5 4,4-dimethylchromane 

Relevant articles and documents

A novel type of retinoic acid receptor antagonist: Synthesis and structure-activity relationships of heterocyclic ring-containing benzoic acid derivatives

A new series of heterocyclic ring-containing benzoic acids was prepared, and the binding affinity and antagonism of its members against all-trans- retinoic acid were evaluated by in vitro assay systems using human promyelocytic leukemia (HL-60) cells. Structure-activity relationships indicated that both an N-substituted pyrrole or pyrazole (1-position) and a hydrophobic region, with these linked by a ring system, were indispensable for effective antagonism. Among the compounds evaluated, optimal antagonism was exhibited by 4-[4,5,7,8,9,10-hexahydro-7,7,10,-10-tetramethyl-1-(3- pyridylmethyl)anthra[1,2-b]pyrrol-3-yl]benzoic acid (31), 4-[4,5,7,8,9,10- hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)-5-thiaanthra[1,2- b]pyrrol-3-yl]benzoic acid (40), and 4-[4,5,7,8,9,10-hexahydro-7,7,10,10- tetramethyl-1-(3-pyridylmethyl)anthra[2,1-d]pyrazol-3-yl]benzoic acid (55), all of which possess a 3-pyridylmethyl group at the five-membered ring nitrogen atom.