40614-27-5

Upstream product

• 40614-20-8 3-(2'-Hydroxyphenyl)-3,3-dimethylpropanol 
• 58584-26-2 ((3-methylbut-3-en-1-yl)oxy)benzene 
• 81255-45-0 Toluene-4-sulfonic acid 3-(2-hydroxy-phenyl)-3-methyl-butyl ester 
• 87077-92-7 2-methyl-4-phenoxy-2-butanol 
• 42007-25-0 diphenyl 3-methyl-3-buten-1-yl phosphate 
• 108-95-2 phenol 
• 7170-38-9 3-phenoxypropanoic acid 
• 54897-52-8 phenyl 3,3-dimethylacrylate 
• 763-32-6 2-methyl-1-buten-4-ol 
• 924-50-5 Methyl 3,3-dimethylacrylate 
• 29598-22-9 4,4-dimethyl-2-oxo-chroman 
• 3350-78-5 3,3-Dimethylacryloyl chloride 
• 7497-89-4 methyl 3-phenoxypropanoate 
• 81246-49-3 3-<2-((methylthio)methoxy)phenyl>-3,3-dimethyl-1-propanol 

Downstream Products

• 87077-92-7 2-methyl-4-phenoxy-2-butanol 
• 88579-23-1 3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl methyl ketone 
• 127255-57-6 4-[(Z)-2-(4,4-Dimethyl-chroman-6-yl)-propenyl]-benzoic acid ethyl ester 
• 88579-22-0 [1-(4,4-dimethyl-6-chromanyl)ethyl]triphenylphosphonium bromide 
• 109140-01-4 methyl 4-<(4,4-dimethyl-6-chromanyl)carbamoyl>benzoate 
• 109140-02-5 4-<(4,4-dimethyl-6-chromanyl)carbamoyl>benzoic acid 
• 1027385-16-5 4-[(4,4-Dimethyl-9-oxo-3,4,6,7,8,9-hexahydro-2H-benzo[g]chromen-8-yl)-hydroxy-methyl]-benzoic acid methyl ester 

Relevant academic research and scientific papers

CHROMAN-SUBSTITUTED, TETRAHYDROQUINOLINE-SUBSTITUTED AND THIOCHROMAN-SUBSTITUTED HETEROAROTINOIDS AS ANTI-CANCER AGENTS

Chemical compounds that inhibit cancer cell growth are provided. The compounds are heteroarotinoids and derivatives thereof with oxygen, nitrogen or sulfur in chroman systems, tetrahydroquinoline systems, and tetrahydrothiochroman systems.

Activity of oxygen-versus sulfur-containing analogs of the Flex-Het anticancer agent SHetA2

Five series of chromans with urea and thiourea linkers connecting a chroman unit (ring A) and a 4-substituted benzene unit (ring B) have been prepared and evaluated relative to SHetA2 (NSC 721689) for activity against the human A2780 ovarian cancer cell l

Co-Catalyzed Hydroarylation of Unactivated Olefins

A mild, general, scalable, and functional group tolerant intramolecular hydroarylation of unactivated olefins using a Co(salen) complex, a N-fluoropyridinium salt, and a disiloxane reagent was reported. This method, which was carried out at room temperature, afforded six-membered benzocyclic compounds from mono-, 1,1- or trans-1,2-di, and trisubstituted olefins.

Friedel-Crafts cyclization of tertiary alcohols using bismuth(III) triflate

Bismuth(III) triflate [Bi(OTf)3] has been developed as an efficient and mild catalyst for intramolecular Friedel-Crafts cyclizations of tertiary alcohols to prepare disubstituted tetrahydronapthalenes, chromans, thiochromans, tetrahydroquinolin

HETEROCYCLIC GPR40 MODULATORS

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Synthesis of heterocycles via ligand-free palladium catalyzed reductive Heck cyclization

Synthesis of five and six membered heterocycles, indolines, 2,3-dihydrobenzofurans, chromans, isochromans, 1,2,3,4-tetrahydroquinolines, and 1,2,3,4-tetrahydroisoquinolines, in 70-99% yield by a ligand-free palladium catalyzed reductive Heck cyclization of phenyl bromides and chlorides, under mild conditions, is reported. Water was found to be essential for these reactions.

Biaromatic compounds and pharmaceutical and cosmetic compositions comprising them

Biaromatic compounds connected by a propynylene or ailenylene bond, corresponding to the formula (I).

Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity

Retinoid-like activity is exhibited by compounds of the formula STR1 where X is S, O, or NR' where R' is hydrogen or lower alkyl; R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-4; and B is H, --COOH or a pharmaceutically acceptable salt, ester or amide thereof, --CH2 OH or an ether or ester derivative, or --CHO or an acetal derivative, or --COR1 or a ketal derivative where R1 is --(CH2)m CH3 where m is 0-4, or a pharmaceutically acceptable salt thereof.

Process for preparing 4,4-dialkyl-6-halo-chromans or thiochromans useful as pharmaceutical intermediates

A process of preparing intermediates useful in making compounds with retinoic acid-like activity is disclosed. The intermediates are halogenated chromans and thiochromans of the formula shown below and are prepared by the alkylation of a phenol or thiophe