1027391-18-9

Upstream product

• 2881-83-6 ethyl 4-methoxybenzoylacetate 
• 441742-49-0 benzyl 3-(4-methoxyphenyl)-3-oxopropionate 
• 100-51-6 benzyl alcohol 
• 530-62-1 1,1'-carbonyldiimidazole 
• 1027029-43-1 2-hydroxy-3-(4-methoxy-phenyl)-3-oxo-propionic acid benzyl ester 

Downstream Products

• 173604-83-6 4-(bromomethyl)-5-(p-methoxyphenyl)-1,3-dioxol-4-en-2-one 
• 173604-86-9 4-(hydroxymethyl)-5-(methoxyphenyl)-1,3-dioxol-4-en-2-one 

Relevant academic research and scientific papers

A general synthesis of dioxolenone prodrug moieties

A general method for the synthesis of dioxolenone prodrug moieties from appropriately substituted β-ketoesters is described. This novel and versatile sequence allows for the synthesis of alkyl- or aryl-substituted dioxolenone alcohols 8 or bromides 9. Coupling of the bromides 9 to prepare bis-dioxolenone phosphonate prodrug esters is also presented.