173604-86-9

Upstream product

• 441742-49-0 benzyl 3-(4-methoxyphenyl)-3-oxopropionate 
• 1027029-43-1 2-hydroxy-3-(4-methoxy-phenyl)-3-oxo-propionic acid benzyl ester 
• 1027391-18-9 5-(4-methoxy-phenyl)-2-oxo-[1,3]dioxole-4-carboxylic acid benzyl ester 
• 2881-83-6 ethyl 4-methoxybenzoylacetate 
• 21086-33-9 2-bromo-1-(4-methoxyphenyl)-1-propanone 
• 15482-28-7 2-hydroxy-1-(4-methoxyphenyl)-propan-1-one 
• 173604-84-7 4-(p-methoxyphenyl)-5-methyl-1,3-dioxol-4-en-2-one 
• 173604-83-6 4-(bromomethyl)-5-(p-methoxyphenyl)-1,3-dioxol-4-en-2-one 
• 172688-06-1 1-p-anisyl-2-(formyloxy)-propan-1-one 

Downstream Products

• 173604-83-6 4-(bromomethyl)-5-(p-methoxyphenyl)-1,3-dioxol-4-en-2-one 

Relevant academic research and scientific papers

A general synthesis of dioxolenone prodrug moieties

A general method for the synthesis of dioxolenone prodrug moieties from appropriately substituted β-ketoesters is described. This novel and versatile sequence allows for the synthesis of alkyl- or aryl-substituted dioxolenone alcohols 8 or bromides 9. Coupling of the bromides 9 to prepare bis-dioxolenone phosphonate prodrug esters is also presented.

Investigation of (oxodioxolenyl)methyl carbamates as nonchiral bioreversible prodrug moieties for chiral amines

The preparation of(oxodioxolenyl)methyl carbamates and their evaluation as novel nonchiral prodrug moieties for chiral primary and secondary amino functional drugs are described. 4-(Carbamoylmethyl)-2-oxo-1,3-dioxolene derivatives of 3,4-dimethoxyphenethy