1027461-44-4

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 126417-82-1 3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-ylamine 
• 1026057-43-1 diethyl 2-[(3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-ylamino)methylene]malonate 

Downstream Products

• 1025798-68-8 4-chloro-3-(4-chloro-phenyl)-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 

Relevant academic research and scientific papers

Discovery of new orally active phosphodiesterase (PDE4) inhibitors

A series of 4-anilinopyrazolopyridine derivatives were synthesized and biologically evaluated as inhibitors of phosphodiesterase (PDE4). Chemical modification of 3, a structurally new chemical lead that was found in our in-house library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chemical lead 5 are presented. Structure-activity relationship data, pharmacological evaluation, and the subtype selectivity study are also presented.