126417-82-1

Basic information

• Product Name: 3-(4-CHLOROPHENYL)-1-METHYL-1H-PYRAZOL-5-AMINE
• Synonyms: BUTTPARK 30\03-79;5-(4-CHLORO-PHENYL)-2-METHYL-2H-PYRAZOL-3-YLAMINE;5-AMINO-3-(4-CHLOROPHENYL)-1-METHYLPYRAZOLE;3-(4-CHLOROPHENYL)-1-METHYL-1H-PYRAZOL-5-AMINE;5-Amino-3-(4-chlorophenyl)-1-methyl-1H-pyrazole;Methyl 2-aMino-5-ethylthiazol-4-carboxylate;3-(4-Chlorophenyl)-1-methyl-1H-pyrazol-5-amine, 1-(5-Amino-1-methyl-1H-pyrazol-3-yl)-4-chlorobenzene
• CAS NO: 126417-82-1
• Molecular Formula: C₁₀H₁₀ClN₃
• Molecular Weight: 207.66
• Mol File: 126417-82-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 150 °C
• Boiling Point: 394.4 °C at 760 mmHg
• Flash Point: 192.3 °C
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 1.99E-06mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(4-CHLOROPHENYL)-1-METHYL-1H-PYRAZOL-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLOROPHENYL)-1-METHYL-1H-PYRAZOL-5-AMINE(126417-82-1)
• EPA Substance Registry System: 3-(4-CHLOROPHENYL)-1-METHYL-1H-PYRAZOL-5-AMINE(126417-82-1)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45
• Hazardous Substances Data: 126417-82-1(Hazardous Substances Data)

Usage

General Description

3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-amine is a chemical compound that belongs to the class of pyrazole derivatives. It is represented by the chemical formula C10H10ClN3 and has a molecular weight of 203.66 g/mol. 3-(4-CHLOROPHENYL)-1-METHYL-1H-PYRAZOL-5-AMINE is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its structure contains a pyrazole ring with a substituted 4-chlorophenyl group and a methyl group, making it useful for medicinal and agricultural applications. The compound's properties and reactivity make it valuable for research and development in the fields of drug discovery and crop protection.

InChI:InChI=1/C10H10ClN3/c1-14-10(12)6-9(13-14)7-2-4-8(11)5-3-7/h2-6H,12H2,1H3

Upstream product

• 7335-27-5 ethyl 4-chlorobenzoate 
• 60-34-4 methylhydrazine 
• 4640-66-8 p-chlorobenzoylacetonitrile 
• 99-91-2 para-chloroacetophenone 
• 78583-86-5 (E)-3-Chloro-3-(4-chloro-phenyl)-acrylonitrile 
• 57-14-7 N,N-Dimethylhydrazine 

Downstream Products

• 639784-26-2 [ 5-(4-CHLORO-PHENYL)-2-METHYL-2H-PYRAZOL-3-YL]-METHYL-AMINE 
• 639784-25-1 [ 5-(4-CHLORO-PHENYL)-2-METHYL-2H-PYRAZOL-3-YL]-THIOPHEN-3-YLMETHYL-AMINE 
• 1610410-98-4 (1,9-bis(4-chlorophenyl)-3,7-dimethyl-3,4,5,6,7,10-hexahydrodipyrazolo[3,4-d:4',3'-g][1,3]diazocine-5,10-diyl)bis((4-chlorophenyl)methanone) 
• 1610410-97-3 (1,9-bis(4-chlorophenyl)-3,7-dimethyl-3,4,5,6,7,10-hexahydrodipyrazolo[3,4-d:4',3'-g][1,3]diazocine-5,10-diyl)bis((4-fluorophenyl)methanone) 
• 1610410-96-2 (1,9-bis(4-chlorophenyl)3,7-dimethyl-3,4,5,6,7,10-hexahydrodipyrazolo[3,4-d:4',3'-g][1,3]diazocine-5,10-diyl)bis(phenylmethanone) 
• 1602492-68-1 (E)-1,2-bis(3-(4-chlorophenyl)-4-iodo-1-methyl-1H-pyrazol-5-yl)diazene 
• 1602492-78-3 (E)-1,2-bis(3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)diazene 
• 1421702-55-7 ethyl 3-(4-chlorophenyl)-4,7-dihydro-1-methyl-4-oxo-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 
• 1421702-39-7 C₂₆H₃₃ClN₄O₂ 
• 1421702-38-6 C₂₅H₃₁ClN₄O₂ 
• 1421702-85-3 3-(4-chlorophenyl)-N-cycloheptyl-4,7-dihydro-1-methyl-4-oxo-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 
• 1421702-84-2 3-(4-chlorophenyl)-N-cyclohexyl-4,7-dihydro-1-methyl-4-oxo-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 
• 1421702-62-6 3-(4-chlorophenyl)-4,7-dihydro-1-methyl-4-oxo-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 1374979-21-1 C₁₅H₁₇BrClN₃O 

Relevant articles and documents

Synthesis and biological evaluation of pyrazolo[3,4-b]pyridin-4-ones as a new class of topoisomerase II inhibitors

A series of 1,3,6-triphenylpyrazolo[3,4-b]pyridin-4-one derivatives was designed, synthesized and evaluated for cytotoxic activity in A375 human melanoma and human erythroleukemia (HEL) cells. The new pyrazolopyridones displayed comparable activities to the antitumor compound etoposide. The inhibitory effect of compounds 17, 18, 27 and 32 against topoisomerase II-mediated cleavage activities was measured finding good correlation with the results obtained from MTS assay. Docking studies into bacterial topoisomerase II (DNA Gyrase), topoisomerase IIα and topoisomerase IIβ binding sites in the DNA binding interface were performed.

Azoles. Part 25: Isomeric 3- and 5-aminopyrazole derivatives

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