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102747-84-2 Usage

General Description

H-Gln(Trt)-OH refers to Nα-(trityl)-L-glutamine, an amino acid derivative with the trityl group protecting the amino group of glutamine. H-Gln(Trt)-OH is commonly used in peptide synthesis and as a building block for the production of peptides and proteins. The trityl group provides protection to the amino group, preventing unwanted side reactions during peptide synthesis. H-Gln(Trt)-OH is often used in solid-phase peptide synthesis and is an important reagent for the construction of complex peptide structures. It is a crucial component in the development of peptide-based drugs and pharmaceuticals.

Check Digit Verification of cas no

The CAS Registry Mumber 102747-84-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,7,4 and 7 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 102747-84:
112 % 10 = 2
So 102747-84-2 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017


1.1 GHS Product identifier

Product name N'-Trityl-L-glutamine

1.2 Other means of identification

Product number -
Other names (2S)-2-amino-5-oxo-5-(tritylamino)pentanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:102747-84-2 SDS

102747-84-2Relevant articles and documents

Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations

Eildal, Jonas N. N.,Hultqvist, Greta,Balle, Thomas,Stuhr-Hansen, Nicolai,Padrah, Shahrokh,Gianni, Stefano,Stromgaard, Kristian,Jemth, Per

, p. 12998 - 13007 (2013)

One of the most frequent protein-protein interaction modules in mammalian cells is the postsynaptic density 95/discs large/zonula occludens 1 (PDZ) domain, involved in scaffolding and signaling and emerging as an important drug target for several diseases

Mild oxidative cleavage of 9-BBN-protected amino acid derivatives

Ankner, Tobias,Norberg, Thomas,Kihlberg, Jan

, p. 3767 - 3770 (2015/06/16)

Protection of the amino acid moiety using 9-BBN is an effective method to enable side chain manipulations in synthesis of complex amino acids. We investigated the standard, mild method for deprotection of the 9-BBN group in methanolic chloroform, and found that it relies on a slow oxidation mediated by molecular oxygen. Building on this insight, we have developed a method that allows for a fast and selective deprotection using simple peroxy acid reagents. After Fmoc protection, products were isolated in >90% yield for a series of amino acid derivatives, including a galactosylated derivative of hydroxylysine. A representative set of 9-BBN-protected amino acid derivatives were efficiently deprotected using peracid reagents in excellent yields. Deprotection is orthogonal with several common protecting groups. Its tolerance of highly acid sensitive groups, such as trityl-protected amides and glycosidic linkages, is especially notable.

Protection of carboxamide functions by the trityl residue. Application to peptide synthesis


, p. 739 - 742 (2007/10/02)

Carboxamide functions may be tritylated by an acid-catalyzed reaction with triphenylmethanol and acetic anhydride in glacial acetic acid. The ω-trityl group of asparagine and glutamine is cleavable by TFA, but stable to strong mineral acids in aqueous solution, as well as to nucleophiles and bases. In peptide syntheses, it is ideally suited for combination with side-chain protections of the t.butyl-type.

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