1027476-96-5 Usage
Uses
Used in Pharmaceutical Research:
N-[(1S,2S)-2-amino cyclohexyl]-N'-[3,5-bis(trifluoromethyl)phenyl]-thiourea is used as a potential drug candidate in pharmaceutical research for its ability to interact with biological targets such as proteins and enzymes. Its promising activities in various biological assays make it a valuable subject for further pharmacological studies.
Used in Organic Synthesis:
In the field of organic synthesis, N-[(1S,2S)-2-amino cyclohexyl]-N'-[3,5-bis(trifluoromethyl)phenyl]-thiourea is used as a building block for the creation of novel compounds with potential therapeutic applications. Its unique structure and functional groups contribute to the development of new molecules with improved properties and therapeutic effects.
Used in Drug Discovery:
N-[(1S,2S)-2-amino cyclohexyl]-N'-[3,5-bis(trifluoromethyl)phenyl]-thiourea is employed in drug discovery processes to identify new therapeutic agents with potential applications in treating various diseases and conditions. Its ability to interact with biological targets makes it a valuable tool in the search for innovative and effective treatments.
Used in Medicinal Chemistry:
In medicinal chemistry, N-[(1S,2S)-2-amino cyclohexyl]-N'-[3,5-bis(trifluoromethyl)phenyl]-thiourea is utilized for the design and optimization of new drug molecules. Its unique structural features and potential to modulate biological targets make it a promising candidate for the development of novel therapeutic agents.
Used in Chemical Biology:
N-[(1S,2S)-2-amino cyclohexyl]-N'-[3,5-bis(trifluoromethyl)phenyl]-thiourea is applied in chemical biology to study the interactions between small molecules and biological systems. Its ability to modulate protein and enzyme activities provides insights into the molecular mechanisms underlying various biological processes and diseases.
Used in Drug Development:
In the drug development industry, N-[(1S,2S)-2-amino cyclohexyl]-N'-[3,5-bis(trifluoromethyl)phenyl]-thiourea is used as a starting point for the synthesis of new drug molecules. Its unique structure and potential therapeutic effects make it a valuable compound for the development of innovative treatments for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1027476-96-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,7,4,7 and 6 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1027476-96:
(9*1)+(8*0)+(7*2)+(6*7)+(5*4)+(4*7)+(3*6)+(2*9)+(1*6)=155
155 % 10 = 5
So 1027476-96-5 is a valid CAS Registry Number.
1027476-96-5Relevant academic research and scientific papers
Catalyst-Controlled Regioselective Chlorination of Phenols and Anilines through a Lewis Basic Selenoether Catalyst
Dinh, Andrew N.,Maddox, Sean M.,Vaidya, Sagar D.,Saputra, Mirza A.,Nalbandian, Christopher J.,Gustafson, Jeffrey L.
, p. 13895 - 13905 (2020/11/03)
We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst, with a catalyst loading as low as 1%. The new catalytic system also allowed us to extend this chemistry to obtain excellent ortho-selectivities for unprotected anilines. The selectivities of this reaction are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approximately 1:4 ortho/para. A series of preliminary studies revealed that the substrates require a hydrogen-bonding moiety for selectivity.
Effective asymmetric Michael addition of acetone to nitroalkenes promoted by chiral proline amide-thiourea bifunctional catalysts
Wang, Qiao-Wei,Peng, Lin,Fu, Ji-Ya,Huang, Qing-Chun,Wang, Li-Xin,Xua, Xiaoying
experimental part, p. 340 - 351 (2010/08/04)
A series of secondary amine-thiourea catalysts 1a-1d derived from L-proline and chiral diamine were prepared and successfully applied to the Michael addition of acetone to trans-nitroalkenes in excellent yields (up to 99%) and enantioselectivities (44-91%
Highly effective and enantioselective α-amination of aldehydes promoted by chiral proline amide-thiourea bifunctional catalysts
Fu, Ji-Ya,Huang, Qing-Chun,Wang, Qiao-Wei,Wang, Li-Xin,Xu, Xiao-Ying
experimental part, p. 4870 - 4873 (2010/10/02)
A series of secondary amine-thiourea catalysts derived from l-proline and chiral diamine were prepared and first applied to highly enantioselective amination of unmodified aldehydes with various azodicarboxylates in excellent yields (up to 99%) and enanti
Effective construction of quaternary stereocenters by highly enantioselective α-amination of branched aldehydes
Fu, Ji-Ya,Xu, Xiao-Ying,Li, Yan-Chun,Huang, Qing-Chun,Wang, Li-Xin
supporting information; experimental part, p. 4524 - 4526 (2010/11/21)
A highly efficient enantioselective α-amination of branched aldehydes with azadicarboxylates promoted by chiral proline-derived amide thiourea bifunctional catalysts was developed for the first time, affording the adducts bearing quaternary stereogenic centers with excellent yields (up to 99%) and enantioselectivities (up to 97% ee).
