1027596-05-9Relevant articles and documents
HIV protease inhibitors: Synthesis and activity of N-aryl-N′- hydroxyalkyl hydrazide pseudopeptides
Marastoni,Baldisserotto,Trapella,McDonald,Bortolotti,Tomatis
, p. 445 - 451 (2007/10/03)
We describe the synthesis and activities of a series of pseudopeptides containing an N-aryl-N′-hydroxyalkyl hydrazide core structure to inhibit human immunodeficiency virus protease and viral replication. Of the series, compound Hmb-Leu-N(Bzl)-N(CH2-CH-OH)-rPro-Boc (24) displayed the greatest inhibitory potency (IC50 1 μM) and exhibited enzymatic resistance and stability in vitro.