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Usage

Uses

Used in Pharmaceutical Synthesis:
1-Indolizinecarboxylic acid, 3-benzoyl-2-phenyl-, ethyl ester is used as a building block in the synthesis of various pharmaceuticals and natural products. Its unique structure and potential biological activities make it a valuable component in the development of new drugs.
Used in Analytical Chemistry:
1-Indolizinecarboxylic acid, 3-benzoyl-2-phenyl-, ethyl ester is used as a reference standard in analytical chemistry. Its well-defined chemical properties allow for accurate measurements and comparisons in various analytical techniques.
Used in Chemical Research:
1-Indolizinecarboxylic acid, 3-benzoyl-2-phenyl-, ethyl ester is used as a reagent in chemical research. Its versatility in chemical reactions and potential for yielding new compounds make it an important tool in the exploration of novel chemical pathways and discoveries.

Upstream product

• 6273-90-1 N-phenacyl-2-chloropyridinium bromide 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 7146-43-2 1-benzoylmethyl-2-bromopyridinium bromide 
• 2739-98-2 ethyl 2-(pyridinyl-2)acetate 
• 94-41-7 benzalacetophenone 
• 5100-57-2 ethyl 2-(2-quinolyl)acetate 
• 614-47-1 1,3-diphenyl-propen-3-one 

Relevant academic research and scientific papers

Iodine-catalyzed [3+2] cyclization of 2-pyridylesters and chalcones: metal-free approach for the synthesis of substituted indolizines

A transition metal-free iodine catalyzed synthesis of indolizine derivatives through [3+2] cyclization of 2-pyridylesters and chalcones has been described. The method is efficient to synthesize a variety of substituted indolizines including hetero aromati

Ligand-free Cu-catalyzed [3 + 2] cyclization for the synthesis of pyrrolo[1,2-a] quinolines with ambient air as a terminal oxidant

A ligand-free Cu-catalyzed [3 + 2] cycloaddition of ethyl 2-(quinolin-2-yl)acetates, ethyl 2-(isoquinolin-1-yl)acetates, and ethyl 2-(pyridin-2-yl)acetates with (E)-chalcones for a "one-pot" synthesis of pyrrolo[1,2-a]quinolines, pyrrolo[2,1-a]isoquinolines and indolizines has been developed. The annulation products were isolated in moderate to good yields with air as the sole oxidant under mild conditions.

Synthesis of Indolizines through Oxidative Linkage of C-C and C-N Bonds from 2-Pyridylacetates

Synthesis of indolizine-1-carboxylates through the Ortoleva-King reaction of 2-pyridylacetate followed by the Aldol condensation under mild reaction conditions has been described. This protocol is compatible with a broad range of functional groups, and it has been also successfully extended to unsaturated ketones, bringing about the regioselective formation of benzoyl-substituted indolizines through Michael addition followed by C-N bond formation, which are difficult to prepare by previous methods in a single step.

The Synthesis of Indolizines: The Reaction of α-Halo Pyridinium Salts with β-Dicarbonyl Species

The reaction of β-keto esters and β-diketones with readily accessible 2-halo pyridinium salts in the presence of DBU serves as a rapid and convenient method for the synthesis of substituted indolizines.The use of diethyl malonate as the dicarbonyl component of the reaction enables the preparation of previously undescribed 2-hydroxyindolizines.