102774-92-5

Basic information

• Product Name: (R)-5-HYDROXY-PIPERIDIN-2-ONE
• Synonyms: RARECHEM AK ML 0203;(R)-5-HYDROXY-PIPERIDIN-2-ONE;2-Piperidinone, 5-hydroxy-, (5R)-;(R)-5-HYDROXY-2-PIPERIDINONE;(5R)-5-Hydroxy-2-piperidinone;2-Piperidinone, 5-hydroxy-, (R)-;(5R)-5-Hydroxypiperidin-2-one
• CAS NO: 102774-92-5
• Molecular Formula: C₅H₉NO₂
• Molecular Weight: 115.13
• Product Categories: pharmacetical
• Mol File: 102774-92-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 352.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.199±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.21±0.20(Predicted)
• CAS DataBase Reference: (R)-5-HYDROXY-PIPERIDIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-HYDROXY-PIPERIDIN-2-ONE(102774-92-5)
• EPA Substance Registry System: (R)-5-HYDROXY-PIPERIDIN-2-ONE(102774-92-5)

Safety Data

• Hazardous Substances Data: 102774-92-5(Hazardous Substances Data)

Usage

General Description

(R)-5-HYDROXY-PIPERIDIN-2-ONE, also known as 5-hydroxypiperidin-2-one, is a chemical compound that belongs to the piperidone class. It is a heterocyclic compound containing a piperidine ring and a hydroxyl group, making it a five-membered lactam. (R)-5-HYDROXY-PIPERIDIN-2-ONE is used in the synthesis of pharmaceuticals and has potential applications in drug discovery and development. It is also used in the preparation of various organic compounds and can serve as a building block for the synthesis of bioactive molecules. Additionally, (R)-5-HYDROXY-PIPERIDIN-2-ONE has been studied for its potential biological activities and pharmacological properties, with some research suggesting its role in anti-cancer and anti-inflammatory activities.

Upstream product

• 58960-19-3 2-{[5-oxotetrahydrofuran-2-yl]methyl}-1H-isoindole-1,3(2H)-dione 
• 102774-93-6 (S)-(5-oxotetrahydrofuran-2-yl)methyl methanesulfonate 
• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 
• 102774-95-8 (R)-(-)-5-Azidomethyl-2-oxotetrahydrofuran 
• 24211-53-8 (S)-(+)-5-Azidomethyl-2-oxotetrahydrofuran 

Downstream Products

• 447408-28-8 5-(tert-butyl-diphenyl-silanyloxy)-1-(toluene-4-sulfonyl)-5,6-dihydro-1H-pyridin-2-one 
• 447408-27-7 5-(tert-butyl-diphenyl-silanyloxy)-1-(toluene-4-sulfonyl)-piperidin-2-one 
• 447408-47-1 5-(tert-butyl-diphenyl-silanyloxy)-3-iodo-1-(toluene-4-sulfonyl)-5,6-dihydro-1H-pyridin-2-one 
• 447408-30-2 3-allyl-5-(tert-butyl-diphenyl-silanyloxy)-1-(toluene-4-sulfonyl)-5,6-dihydro-1H-pyridin-2-one 
• 447408-46-0 5-(tert-butyl-diphenyl-silanyloxy)-3-phenylselanyl-1-(toluene-4-sulfonyl)-piperidin-2-one 
• 447408-34-6 8a-allyl-4-(tert-butyl-diphenyl-silanyloxy)-2-(toluene-4-sulfonyl)-3,4,4a,8a-tetrahydro-2H,5H-isoquinoline-1,6-dione 
• 447408-33-5 8a-allyl-6-(tert-butyl-dimethyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxy)-8-dimethylamino-2-(toluene-4-sulfonyl)-3,4,4a,5,8,8a-hexahydro-2H-isoquinolin-1-one 
• 143900-43-0 tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate 
• 447408-45-9 5-tert-Butyldimethylsiloxy-2-piperidone 

Relevant articles and documents

A practical and enantiospecific synthesis of (-)-(R)- and (+)-(S)-piperidin-3-ols

A highly enantiospecific, azide-free synthesis of (-)-(R)- and (+)-(S)-piperidin-3-ol in excellent yield was developed. The key step of the synthesis involves the enantiospecific ring openings of enantiomerically pure (R)- and (S)-2-(oxiran-2-ylmethyl)-1H-isoindole-1,3(2H)-diones with the diethyl malonate anion and subsequent decarboxylation.

Chirospecific synthesis of (S)-(+)- and (R)-(-)-5-amino-4- hydroxypentanoic acid from L- and D-glutamic acid via (S)-(+)- and (R)-(-)-5-hydroxy-2-oxopiperidine

-