102774-92-5 Usage
Uses
Used in Pharmaceutical Synthesis:
(R)-5-HYDROXY-PIPERIDIN-2-ONE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Drug Discovery and Development:
In the field of drug discovery and development, (R)-5-HYDROXY-PIPERIDIN-2-ONE is used as a chemical scaffold to explore and create novel bioactive compounds that can address unmet medical needs.
Used in Organic Chemistry:
(R)-5-HYDROXY-PIPERIDIN-2-ONE is used as a building block in organic chemistry for the preparation of a range of organic compounds, highlighting its versatility in chemical synthesis.
Used in Biological Research:
(R)-5-HYDROXY-PIPERIDIN-2-ONE is utilized in biological research as a subject of study for its potential biological activities, including roles in anti-cancer and anti-inflammatory processes, which could lead to the discovery of new therapeutic agents.
Used in the Preparation of Bioactive Molecules:
In the synthesis of bioactive molecules, (R)-5-HYDROXY-PIPERIDIN-2-ONE is used as a precursor to create compounds that can interact with biological targets, potentially leading to new treatments for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 102774-92-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,7,7 and 4 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 102774-92:
(8*1)+(7*0)+(6*2)+(5*7)+(4*7)+(3*4)+(2*9)+(1*2)=115
115 % 10 = 5
So 102774-92-5 is a valid CAS Registry Number.
102774-92-5Relevant articles and documents
A practical and enantiospecific synthesis of (-)-(R)- and (+)-(S)-piperidin-3-ols
Babu, Meruva Suresh,Raghunadh, Akula,Ramulu, Konda,Dahanukar, Vilas H.,Syam Kumar, Unniaran K.,Dubey, P. Kumar
, p. 1507 - 1515 (2015/02/19)
A highly enantiospecific, azide-free synthesis of (-)-(R)- and (+)-(S)-piperidin-3-ol in excellent yield was developed. The key step of the synthesis involves the enantiospecific ring openings of enantiomerically pure (R)- and (S)-2-(oxiran-2-ylmethyl)-1H-isoindole-1,3(2H)-diones with the diethyl malonate anion and subsequent decarboxylation.
Enantioenriched N-(2-Chloroalkyl)-3-acetoxypiperidines as Potential Cholinotoxic Agents. Synthesis and Preliminary Evidence for Spirocyclic Aziridinium Formation.
Huh, Nam,Thompson, Charles M.
, p. 5935 - 5950 (2007/10/02)
The syntheses of six enantioenriched analogs representing cyclic forms of acetylcholine are reported. (S)- and (R)-N-(2-chloroethyl)-3-acetoxypiperidine and (R,R)-, (R,S)-, (S,R)-, and (S,S)-N-(2-chloropropyl)-3-acetoxypiperidine have been synthesized from (R)- or (S)-3-hydroxypiperidine in five steps. (R)- and (S)-3-hydroxypiperidine were accessed via parallel stereospecific routes from d- and l-glutamic acid, and through fractional recrystallization of diastereomeric tartranilic acid salts. (S)-N-(2-Chloroethyl)-3-acetoxypiperidine was reacted with silver perchlorate to form a spirocyclic aziridinium analog of acetylcholine as evidenced by a characteristic 1H NMR shift for the aziridinium methylene groups.
