447408-45-9

Upstream product

• 102774-92-5 (R)-(+)-5-Hydroxy-2-oxopiperidine 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 447408-33-5 8a-allyl-6-(tert-butyl-dimethyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxy)-8-dimethylamino-2-(toluene-4-sulfonyl)-3,4,4a,5,8,8a-hexahydro-2H-isoquinolin-1-one 
• 447408-36-8 8a-allyl-4-(tert-butyl-diphenyl-silanyloxy)-2-(toluene-4-sulfonyl)-6-trimethylsilanyloxy-3,4,4a,8a-tetrahydro-2H-isoquinolin-1-one 
• 447408-34-6 8a-allyl-4-(tert-butyl-diphenyl-silanyloxy)-2-(toluene-4-sulfonyl)-3,4,4a,8a-tetrahydro-2H,5H-isoquinoline-1,6-dione 
• 447408-46-0 5-(tert-butyl-diphenyl-silanyloxy)-3-phenylselanyl-1-(toluene-4-sulfonyl)-piperidin-2-one 
• 447408-30-2 3-allyl-5-(tert-butyl-diphenyl-silanyloxy)-1-(toluene-4-sulfonyl)-5,6-dihydro-1H-pyridin-2-one 
• 447408-47-1 5-(tert-butyl-diphenyl-silanyloxy)-3-iodo-1-(toluene-4-sulfonyl)-5,6-dihydro-1H-pyridin-2-one 
• 447408-28-8 5-(tert-butyl-diphenyl-silanyloxy)-1-(toluene-4-sulfonyl)-5,6-dihydro-1H-pyridin-2-one 
• 447408-27-7 5-(tert-butyl-diphenyl-silanyloxy)-1-(toluene-4-sulfonyl)-piperidin-2-one 

Relevant academic research and scientific papers

Evaluation of diene hierarchies for Diels-Alder reactions en route to xestocyclamine A: Elaboration of an ansa bridge by B-alkyl Suzuki macrocyclization

A double Michael addition of amine 2 to 1 was a key reaction in the synthesis of the isoquinuclidine core 4 of xestocyclamine A, a protein kinase C inhibitor. The first ansa bridge was formed efficiently by a B-alkyl Suzuki coupling in 3. TBDPS = tert-but

Reductive deamination of α-amino carbonyl compounds by means of samarium iodide

Reaction of α-amino carbonyl compounds with SmI2 in THF-HMPA in the presence of a proton source afforded the deamination products, where the fragmentation occurred between the nitrogen and the carbon α to the carbonyl group.