1027824-76-5

Basic information

• Product Name: 1-(8-amino-4,4-diethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,6-dichloro-phenyl)-thiourea
• Synonyms: 1-(8-amino-4,4-diethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,6-dichloro-phenyl)-thiourea
• CAS NO: 1027824-76-5
• Molecular Weight: 451.376
• Mol File: 1027824-76-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(8-amino-4,4-diethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,6-dichloro-phenyl)-thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(8-amino-4,4-diethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,6-dichloro-phenyl)-thiourea(1027824-76-5)
• EPA Substance Registry System: 1-(8-amino-4,4-diethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,6-dichloro-phenyl)-thiourea(1027824-76-5)

Safety Data

• Hazardous Substances Data: 1027824-76-5(Hazardous Substances Data)

Upstream product

• 6590-95-0 2,6-dichlorophenylisothiocyanate 
• 99911-06-5 7,8-diamino-4,4-diethyl-4H-isoquinoline-1,3-dione 
• 99911-24-7 N-(4,4-diethyl-8-nitro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-acetamide 
• 99911-29-2 7-amino-4,4-diethyl-8-nitro-4H-isoquinoline-1,3-dione 
• 99911-20-3 N-(4,4-diethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-acetamide 
• 99911-13-4 4,4-diethyl-7-nitro-4H-isoquinoline-1,3-dione 
• 99911-16-7 7-amino-4,4-diethyl-4H-isoquinoline-1,3-dione 
• 1027535-06-3 2-(1-cyano-1-ethylpropyl)benzonitrile 
• 29777-45-5 4,4-diethyl-4H-isoquinoline-1,3-dione 
• 3759-28-2 (2-cyanophenyl)acetonitrile 

Relevant articles and documents

Discovery of 2-phenylamino-imidazo[4,5-h]isoquinolin-9-ones: A new class of inhibitors of lck kinase

An imidazo[4,5-h]isoquinolin-7,9-dione (1) was identified as an adenosine 5′-triphosphate competitive inhibitor of lck by high throughput screening. Initial structure-activity relationship studies identified the dichlorophenyl ring and the imide NH as important pharmacophores. A binding model was constructed to understand how 1 binds to a related kinase, hck. These results suggested that removing the gem-dimethyl group and flattening the ring would enhance activity. This was realized by converting 1 to the imidazo[4,5-h]isoquinolin-9-one (20), resulting in an 18-fold improvement in potency against lck and a 50-fold increase in potency in a cellular assay.