6590-95-0

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Dichlorophenyl isothiocyanate is used as a precursor for the synthesis of 1-(2-aminoethyl)-2-cyano-3-(2,6-dichlorophenyl)guanidine. This synthesized compound has potential applications in the development of pharmaceuticals, particularly those targeting specific medical conditions.
In the synthesis process, 2,6-dichlorophenyl isothiocyanate serves as a crucial intermediate, contributing to the formation of the final product with desired therapeutic properties. Its role in the pharmaceutical industry highlights the importance of understanding and utilizing chemical compounds for the development of new drugs and treatments.

InChI:InChI=1/C7H3Cl2NS/c8-5-2-1-3-6(9)7(5)10-4-11/h1-3H

Upstream product

• 463-71-8 thiophosgene 
• 608-31-1 2,6-Dichloroaniline 
• 6579-27-7 2,6-dichlorobenzohydroximoyl chloride 
• 4921-82-8 1-benzoyl-3-phenylthiourea 
• 4921-83-9 1-benzoyl-3-(4-chloro-phenyl)-thiourea 
• 3385-55-5 N,N'-dibenzhydryl-thiourea 
• 591-08-2 acetylthiourea 
• 25185-95-9 2,6-dichlorobenzaldoxime 
• 33663-43-3 2,6-dichloroaniline hydrochloride 
• 6579-27-7 2,6-Dichloro-N-hydroxybenzenecarboximidoyl chloride 
• 96938-54-4 N-benzoyl-N′-(2,4,6-trichlorophenyl)-thiourea 
• 37143-74-1 1-mesityl-3-phenylthiourea 
• 28010-77-7 1-Benzoyl-1,3-dibenzylthioharnstoff 
• 17356-08-0 thiourea 

Downstream Products

• 50470-13-8 (2,6-dichloro-phenyl)-thiazolo[5,4-b]pyridin-2-yl-amine 
• 59801-64-8 1,1-dioxo-thiomorpholine-4-carbothioic acid 2,6-dichloro-anilide 
• 64892-99-5 (2,6-dichloro-phenyl)-(4-methylene-3-thia-1-aza-spiro[4.5]dec-1-en-2-yl)-amine 
• 57438-15-0 1-benzothiazol-2-ylmethyl-3-(2,6-dichloro-phenyl)-1-(2-hydroxy-ethyl)-thiourea 
• 65295-77-4 1-(2,6-dichlorophenyl)-3-[2-(1-piperidino)ethyl]-2-thiourea 
• 75257-64-6 1-(2,6-Dichloro-phenyl)-3-(2-hydroxy-ethyl)-thiourea 
• 115934-15-1 3-(2,6-Dichloro-phenyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 75257-70-4 1-(3-Amino-propyl)-3-(2,6-dichloro-phenyl)-thiourea 
• 75257-74-8 1-(2-Cyano-ethyl)-3-(2,6-dichloro-phenyl)-thiourea 
• 75236-16-7 C₈H₄Cl₂N₃S^(1-)*Na⁽¹⁺⁾ 
• 75257-76-0 2-[3-(2,6-Dichloro-phenyl)-thioureido]-ethanesulfonic acid amide 
• 113400-77-4 2-(o,o'-dichlorophenylthiocarbamoyl)-9-methyl-1,2,3,4-tetrahydro-11H-dipyrido<1,2-a:4,3-d>pyrimidin-11-one 
• 29263-30-7 (2,6-dichloro-phenyl)-(4,5-dihydro-thiazol-2-yl)-amine 
• 75257-65-7 1-(2,6-Dichloro-phenyl)-3-(2-methylamino-ethyl)-thiourea 

Relevant academic research and scientific papers

Heterocyclic compounds as FGFR4 inhibitors

The present invention provides heterocyclic compounds as selective inhibitors of fibroblast growth factor receptor 4 (FGFR4), pharmaceutical compositions containing the compounds, methods of preparingthe compounds, and methods of treating cell proliferative diseases, such as cancer, using the compounds of the invention.

Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1

This letter describes the synthesis and biological evaluation of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as novel mPGES-1 inhibitors, capable of inhibiting an increased PGE2 production in the disease state. Structure-activity optimization afforded many potent mPGES-1 inhibitors having 50 of 14.3 mg/kg in guinea pig.

NOVEL FLAVONE BASED EGFR INHIBITORS AND PROCESS FOR PREPARATION THEREOF

The present invention discloses a novel EGFR inhibitor compound of formula (1), process for preparation thereof and methods of treating abnormal cell growth in mammals by administering the compounds of formula (1). wherein, R is selected from hydrogen, alkyl, nitro, halogens such as chlorine, bromine, fluorine and iodine; Rl= hydrogen, alkyl, alkoxy, aryl, nitro, halogens such as chlorine, bromine, fluorine and iodine, trifluoromethyl, thioalkyl, trifluromethoxy, trialkylsilyl.

Double three bromo 1,3-di-pyridine salt-based propane and its preparation method, method of use, recovery method and application

The invention discloses a double tribromo 1,3-bipyridine onium salt dimethylmethane, and a preparation method, an application method, a recovery method and application thereof. The preparation method comprises the following steps: dissolving 1,3-bipyridine onium salt dimethylmethane by using water, and then adding potassium bromide; adding potassium peroxymonosulfate sulfate compound brine solution to prepare a clear solution after dissolving potassium bromide, and then stirring and reacting at -10 to 0 DEG C until solid is separated out; separating out solid, so as to obtain the double tribromo 1,3-bipyridine onium salt dimethylmethane. The product can be used for preparing isothiocyanate, aromatic thiourea or acetanilide. The preparation method disclosed by the invention is mild in condition, and simple to operate the reaction process, and raw materials are easily available. The double tribromo 1,3-bipyridine onium salt dimethylmethane not only can be used as a brominating reagent, but also can be used as organic synthesis intermediates, meanwhile, the reaction efficiency is improved, and the double tribromo 1,3-bipyridine onium salt dimethylmethane is convenient to recover and can be recycled.

Tricyclic Compounds As mPGES-1 Inhibitors

The present invention relates to tricyclic compounds of formula (I) or pharmaceutically acceptable salt thereof as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.

Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors

The serine protease urokinase (uPa) has been implicated in the progression of both breast and prostate cancer. Utilizing structure based design, the synthesis of a series of substituted 4-[2-amino-1,3-thiazolyl]-thiophene-2-carboxamidines is described. Further optimization of this series by substitution of the terminal amine yielded urokinase inhibitors with excellent activities.

Dihydro-1,2,4-triazin-6(1H)-ones. IV Chemical modification of 3-phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-ones

Reaction of 3-phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-one (1) and its 5,5-dimethyl derivative (4) with phosphorus pentasulfide gave the corresponding 6-thiones (2) and (5); methylation of (2) gave the 6-methylsulfanyl-3-phenyl-4,5-dihydro-1,2,4-triazine (3), also obtained by reaction of 6-chloro-3-phenyl-4,5-dihydro-1,2,4-triazine (8) with sodium thiomethoxide. Reaction of (8) with morpholine afforded the 6-(morpholin-4′-yl) derivative (9). Reaction of (1) with isopropyl isocyanate gave N-isopropyl-6-oxo-3-phenyl-1,4,5,6-tetrahydro-1,2,4-triazine-1-carboxamide (19a), and a Mannich reaction of (1) with morpholine and formaldehyde gave the 1-morpholinomethylene derivative (20a). Attempts to effect cycloaddition of 1-methyl-3-phenyl-1,2,4-triazin-6(1H)-one (12) with a benzonitrile oxide failed. Reaction of the thione (2) with 1,3-dipolarophiles gave unstable adducts. CSIRO 2000.

A study on the stability of 5,5-diamino-substituted- 1,4,2- oxathiazoline derivatives

5,5-Diamino-substituted-1,4,2-oxathiazoline derivatives 3 as potential prodrugs, which were easily prepared from hydroximoyl chlorides I and the appropriate thiourea derivatives 2, were decomposed instantaneously into isothiocyanates 4 and the corresponding urea derivatives 5 irrespective of the substituents.

A facile one-pot preparation of isothiocyanates from aldoximes

Isothiocyanates 2a-l were prepared in excellent yields in a one-pot reaction from aldoxime derivatives 1a-l by successive treatment of aldoxime with N-chlorosuccinimide (NCS), thiourea, and triethylamine. The use of HCl/DMF/Oxone system in the reaction instead of NCS was equally effective.