102793-81-7

Usage

Uses

Used in Organic Synthesis:
1-(2-Bromoethoxy)-4-(trifluoromethoxy)benzene is used as a building block in the synthesis of various organic compounds, contributing to the development of novel chemical entities with potential applications across different industries.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(2-Bromoethoxy)-4-(trifluoromethoxy)benzene is utilized as a key component in the development of new pharmaceutical drugs. Its unique structure and properties allow for the exploration of its potential therapeutic effects and integration into drug design strategies.
Safety Precautions:
It is crucial to handle 1-(2-Bromoethoxy)-4-(trifluoromethoxy)benzene with care, as it may present certain health risks if not used properly. Adequate safety measures should be taken to minimize any potential hazards associated with its use.

Upstream product

• 828-27-3 4-Trifluoromethoxyphenol 
• 106-93-4 ethylene dibromide 

Downstream Products

• 1418287-59-8 methyl 4-chloro-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxylate 
• 1418287-60-1 4-(2-fluoropyridin-4-yl)-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid potassium salt 
• 1186134-34-8 C₁₃H₁₇F₃N₂O₂ 
• 1352874-91-9 thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone 
• 1352792-19-8 thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone hydrochloride 
• 1422463-29-3 2-(2-((2-(4-(trifluoromethoxy)phenoxy)ethyl)amino)ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione 

Relevant academic research and scientific papers

Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I)

Kv1.5 potassium channel is an efficacious and safe therapeutic target for the treatment of atrial fibrillation (AF), the most common arrhythmia that threatens human. Herein, by modifying the hit compound 7k from an in-house database, 48 derivatives were synthesized for the assay of their Kv1.5 inhibitory effects by whole cell patch clamp technique. Six compounds which showed better potency than the positive compound dronedarone were selected for the next evaluation of their drug-like properties. Compound 8 exhibited balanced solubility and permeability. It also showed acceptable pharmacodynamics profile with very low acute toxicity. Taking all these data into account, compound 8 can serve as a promising lead for the development of novel therapeutic agent for the treatment of AF.

TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF

The present invention is directed to compounds of formula I and la: which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, t

Development of unsymmetrical dyads as potent noncarbohydrate-based inhibitors against human β-N-acetyl-D-hexosaminidase

Human β-N-acetyl-D-hexosaminidase has gained much attention due to its roles in several pathological processes and been considered as potential targets for disease therapy. A novel and efficient skeleton, which was an unsymmetrical dyad containing naphthalimide and methoxyphenyl moieties with an alkylamine spacer linkage as a noncarbohydrate-based inhibitor, was synthesized, and the activities were valuated against human β-N-acetyl-D- hexosaminidase. The most potent inhibitor exhibits high inhibitory activity with Ki values of 0.63 μM. The straightforward synthetic manners of these unsymmetrical dyads and understanding of the binding model could be advantageous for further structure optimization and development of new therapeutic agents for Hex-related diseases.

Novel cyclic amide derivatives

Novel compounds represented by the following formula (I) that act as a ligand to sigma receptor/binding cite and a medicament comprising the same as an active ingredient: wherein X represents an alkyl group, an aryl group, a heterocyclic group or the like; Q represents a group represented by —CH2—, —CO—, —O—, —CH(OR7)— or the like wherein R7 represents a hydrogen atom, an alkyl group or the like; n represents an integer of from 0 to 5; R1 and R2 each represent a hydrogen atom, an alkyl group or the like; B represents either of the following groups: wherein R3, R4, R5, and R6 each represent a hydrogen atom, a halogen atom, an alkoxyl group or the like; m represents 1 or 2; and the ring of: represents an aromatic heterocyclic ring.