102804-00-2

Upstream product

• 5399-92-8 4-chloro-1H-pyrazolo[3,4-d]pyrimidine 
• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 91713-47-2 4-chloro-1-<2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidine 

Relevant academic research and scientific papers

Synthesis and Hydrolytic Stability of 4-Substituted Pyrazolopyrimidine 2'-Deoxyribofuranosides

Phase-transfer glycosylation of 4-chloro-1H-pyrazolopyrimidine (1) with 2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl chloride (2) yielded the N-1 glycosylation product (3) in 42 percent.The protected intermediate (3) was converted into pyrazolopyrimidine 2'-deoxyribofuranosides with amino, oxo, and thioxo substituents at C-4.Kinetic data of proton-catalysed hydrolysis showed that pyrazolopyrimidine 2'-deoxyribofuranosides are more stable at the N-glycosylic bond than are the parent purine nucleosides.