91713-47-2Relevant articles and documents
Synthesis and Hydrolytic Stability of 4-Substituted Pyrazolopyrimidine 2'-Deoxyribofuranosides
Seela, Frank,Steker, Herbert
, p. 2573 - 2576 (2007/10/02)
Phase-transfer glycosylation of 4-chloro-1H-pyrazolopyrimidine (1) with 2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl chloride (2) yielded the N-1 glycosylation product (3) in 42 percent.The protected intermediate (3) was converted into pyrazolopyrimidine 2'-deoxyribofuranosides with amino, oxo, and thioxo substituents at C-4.Kinetic data of proton-catalysed hydrolysis showed that pyrazolopyrimidine 2'-deoxyribofuranosides are more stable at the N-glycosylic bond than are the parent purine nucleosides.