102818-44-0Relevant academic research and scientific papers
INHIBITORS OF FOCAL ADHESION KINASE
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Page/Page column 131, (2008/12/07)
The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.
Heterocyclen-Synthesen mit Monothiomalonsaeure-Amiden: Synthese von 3-Oxo-2,3-dihydroisothiazolopyridinen und 3-Oxo-2,3-dihydroisothiazolopyrimidinen
Schaper, Wolfgang
, p. 861 - 867 (2007/10/02)
The monothiomalonic acid amides 5, prepared from cyanoacetamides 4 and hydrogen sulphide, react with diketones 6 or aldehyde derivatives 7 to give the 2-thioxo-1,2-dihydropyridine-3-carboxamides 8 which can be cyclised to the 3-oxo-2,3-dihydroisothiazolo
