10282-60-7Relevant articles and documents
Green and efficient method for the acylation of amines and phenols in the presence of hydrotalcite in water
Massah, Ahmad Reza,Toghyani, Mitra,Najafabadi, Batool Hojati
, p. 603 - 605,3 (2012)
In this study a mild, efficient and environmentally friendly method has been developed for the synthesis of amides and esters in the presence of hydrotalcite in water at room temperature. Different types of amines and phenols have been used and in all cases the products were obtained in moderate to high yields after an easy work-up. This method follows the principles of green chemistry.
NOVEL CARBOCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS
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Paragraph 27; 46; 47, (2017/03/21)
The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.