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Upstream product

• 611-74-5 N,N-dimethylbenzamide 
• 1026592-89-1 [1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-4-(2,2-dimethoxy-ethylcarbamoyl)-2-oxo-6-phenyl-1,2-dihydro-pyridin-3-yl]-carbamic acid benzyl ester 
• 159780-57-1 2-(3-Benzyloxycarbonylamino-4-ethoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1isopropylpropyl)acetamide 
• 159780-58-2 2-(3-Benzyloxycarbonylamino-4-carboxy-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 159780-55-9 2-(4-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 159780-56-0 2-(3-Carboxy-4-ethoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 159780-13-9 2-phthalimido-N-<2-<(tert-butyldimethylsiloxy)oxy>-3,3,3-trifluoro-1-isopropyl>acetamide 
• 159780-12-8 2-phthalimido-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide 
• 159780-14-0 2-amino-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropyl>acetamide 
• 174740-67-1 dimethyl <2-(ethoxycarbonyl)ethylidene>malonate 
• 2397-26-4 N,N-dimethyl(chlorophenylmethylene)ammonium chloride 
• 1026256-09-6 N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[3-(2,2-dimethoxy-ethyl)-2,4,8-trioxo-6-phenyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-acetamide 

Relevant academic research and scientific papers

Nonpeptidic inhibitors of human neutrophil elastase. 7. Design, synthesis, and in vitro activity of a series of pyridopyrimidine trifluoromethyl ketones

Using molecular modeling and the information derived from X-ray crystal structures of human neutrophil elastase (HNE) and porcine pancreatic elastase (PPE) complexed to peptidic ligands, we have developed a new series of nonpeptidic inhibitors of HNE, the