1028330-53-1

Basic information

• Product Name: 2-(2,6-diethyl-phenyl)-4-methoxy-5,6,7,8-tetrahydro-quinolin-5-ol
• Synonyms: 2-(2,6-diethyl-phenyl)-4-methoxy-5,6,7,8-tetrahydro-quinolin-5-ol
• CAS NO: 1028330-53-1
• Molecular Weight: 311.424
• Mol File: 1028330-53-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(2,6-diethyl-phenyl)-4-methoxy-5,6,7,8-tetrahydro-quinolin-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-diethyl-phenyl)-4-methoxy-5,6,7,8-tetrahydro-quinolin-5-ol(1028330-53-1)
• EPA Substance Registry System: 2-(2,6-diethyl-phenyl)-4-methoxy-5,6,7,8-tetrahydro-quinolin-5-ol(1028330-53-1)

Safety Data

• Hazardous Substances Data: 1028330-53-1(Hazardous Substances Data)

Upstream product

• 1028330-52-0 2-(2,6-diethyl-phenyl)-4-methoxy-7,8-dihydro-6H-quinolin-5-one 

Downstream Products

• 1028331-11-4 5-chloro-2-(2,6-diethylphenyl)-4-methoxy-5,6,7,8-tetrahydroquinoline 

Relevant articles and documents

Synthesis and characterization of 5,6,7,8-tetrahydroquinoline C5a receptor antagonists

A novel series of substituted 2-aryl-5-amino-5,6,7,8-tetrahydroquinoline C5a receptor antagonists is reported. Synthetic routes were developed that allow the substituents on the tetrahydroquinoline core to be efficiently varied, facilitating determination of structure-activity relationships. Members of the series display high binding affinity for the C5a receptor and are potent functional antagonists.

Design and optimization of aniline-substituted tetrahydroquinoline C5a receptor antagonists

A series of aniline-substituted tetrahydroquinoline C5a receptor antagonists were discovered. A functionality requirement of ortho substitution on the aniline was revealed. Secondary anilines, in general, outperformed tertiary analogs in inhibition of C5a-induced calcium mobilization. Further enhancement of activity was realized in the presence of an ortho hydroxyalkyl side chain. The functional IC50 of selected analogs was optimized to the single-digit nanomolar level.