1028331-11-4

Basic information

• Product Name: 5-chloro-2-(2,6-diethylphenyl)-4-methoxy-5,6,7,8-tetrahydroquinoline
• Synonyms: 5-chloro-2-(2,6-diethylphenyl)-4-methoxy-5,6,7,8-tetrahydroquinoline
• CAS NO: 1028331-11-4
• Molecular Weight: 329.87
• Mol File: 1028331-11-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-chloro-2-(2,6-diethylphenyl)-4-methoxy-5,6,7,8-tetrahydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-(2,6-diethylphenyl)-4-methoxy-5,6,7,8-tetrahydroquinoline(1028331-11-4)
• EPA Substance Registry System: 5-chloro-2-(2,6-diethylphenyl)-4-methoxy-5,6,7,8-tetrahydroquinoline(1028331-11-4)

Safety Data

• Hazardous Substances Data: 1028331-11-4(Hazardous Substances Data)

Upstream product

• 1028330-53-1 2-(2,6-diethyl-phenyl)-4-methoxy-5,6,7,8-tetrahydro-quinolin-5-ol 

Downstream Products

• 1028330-57-5 C₃₀H₃₃F₃N₂O 
• 1028330-60-0 C₂₉H₃₃FN₂O 
• 1028330-63-3 C₃₁H₃₆N₂O₃ 
• 1028330-64-4 C₃₀H₃₃F₃N₂O 
• 1028330-55-3 C₂₉H₃₄N₂O 
• 1028330-61-1 C₃₀H₃₆N₂O₂ 
• 1028330-86-0 [2-(2,6-diethyl-phenyl)-4-methoxy-5,6,7,8-tetrahydro-quinolin-5-yl]-ethyl-naphthlen-1-yl-amine 
• 1046488-98-5 C₂₇H₃₂N₂O₂ 
• 1046489-04-6 C₂₈H₃₄N₂O₂ 
• 1046488-80-5 C₂₈H₃₁F₃N₂O 
• 1046488-76-9 C₂₇H₃₁FN₂O 
• 1046488-99-6 C₂₇H₃₁ClN₂O₂ 
• 1046489-02-4 C₂₇H₃₁ClN₂O₂ 
• 1046488-89-4 C₃₃H₃₆N₂O₂ 

Relevant articles and documents

SUBSTITUTED 5,6,7,8-TETRAHYDROQUINOLINE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE THEREOF

Substituted 5,6,7,8-tetrahydroquinoline derivatives, which are C5a receptor modulators, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, immune and inflammatory diseases and conditions, are disclosed.

Design and optimization of aniline-substituted tetrahydroquinoline C5a receptor antagonists

A series of aniline-substituted tetrahydroquinoline C5a receptor antagonists were discovered. A functionality requirement of ortho substitution on the aniline was revealed. Secondary anilines, in general, outperformed tertiary analogs in inhibition of C5a-induced calcium mobilization. Further enhancement of activity was realized in the presence of an ortho hydroxyalkyl side chain. The functional IC50 of selected analogs was optimized to the single-digit nanomolar level.