1028330-63-3Relevant articles and documents
Synthesis and characterization of 5,6,7,8-tetrahydroquinoline C5a receptor antagonists
Barbay, J. Kent,Gong, Yong,Buntinx, Mieke,Li, Jian,Claes, Concha,Hornby, Pamela J.,Van Lommen, Guy,Van Wauwe, Jean,He, Wei
, p. 2544 - 2548 (2008/12/21)
A novel series of substituted 2-aryl-5-amino-5,6,7,8-tetrahydroquinoline C5a receptor antagonists is reported. Synthetic routes were developed that allow the substituents on the tetrahydroquinoline core to be efficiently varied, facilitating determination of structure-activity relationships. Members of the series display high binding affinity for the C5a receptor and are potent functional antagonists.