1028432-87-2

Upstream product

• 1028432-64-5 C₄₅H₅₈O₅Si 
• 908865-92-9 (2S,3S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2-methyl-hexan-1-ol 
• 1028432-61-2 C₅₂H₆₄O₆Si 
• 1028432-85-0 C₅₂H₆₆O₇Si 
• 351186-81-7 Phosphoric acid (6S,7R)-6-benzyloxy-7-benzyloxymethyl-4,5,6,7-tetrahydro-oxepin-2-yl ester diphenyl ester 
• 250226-96-1 (6S,7R)-6-Benzyloxy-7-benzyloxymethyl-oxepan-2-one 
• 1360872-80-5 C₂₁H₂₈O₄ 
• 1360872-86-1 C₂₅H₃₆O₆ 
• 1360872-85-0 C₁₁H₂₄O₆ 
• 1360872-84-9 C₁₈H₂₈O₆ 
• 1360873-03-5 C₁₆H₂₂O₅ 
• 1206828-93-4 C₁₄H₂₀O₄ 
• 1028432-60-1 C₃₁H₄₁IO₃Si 
• 1028432-63-4 C₄₆H₆₀O₅SSi 

Downstream Products

• 1028432-65-6 C₄₀H₆₆O₅Si₂ 
• 1028432-66-7 C₄₀H₆₄O₄Si₂ 
• 1360872-87-2 C₄₀H₆₆O₆Si₂ 
• 1360873-07-9 C₄₄H₇₄O₈Si₂ 
• 1360872-89-4 C₂₆H₄₂O₈ 
• 1360873-09-1 C₂₆H₄₁IO₇ 
• 1360872-79-2 C₂₆H₄₀O₇ 
• 1360873-14-8 C₄₃H₇₀O₆Si₂ 

Relevant academic research and scientific papers

Total synthesis of (-)-brevenal: A streamlined strategy for practical synthesis of polycyclic ethers

We describe a streamlined strategy for the practical synthesis of trans-fused polycyclic ethers and its application to a concise total synthesis of (-)-brevenal, a new pentacyclic polyether natural product with intriguing biological activities. The B-, D-, and E-rings were constructed by TEMPO/PhI(OAc)2-mediated oxidative lactonization of the corresponding 1,6-diols, with minimal need for manipulation of oxygen functionalities. The B- and E-ring lactones were appropriately functionalized by Suzuki-Miyaura coupling of lactone-derived enol phosphates and subsequent stereoselective hydroboration. The A-ring was formed by our mixed thioacetalization methodology. The AB- and DE-ring fragments were assembled through Suzuki-Miyaura coupling, and the C-ring was forged in the same manner as that for the A-ring. More than two grams of the pentacyclic polyether core of (-)-brevenal have been synthesized by the synthetic route developed in this study.

Total synthesis of (-)-brevenal: A concise synthetic entry to the pentacyclic polyether core

(Chemical Equation Presented) Total synthesis of (-)-brevenal, a novel marine polycyclic ether natural product, is described. Highly efficient and scalable entries to the AB-ring exo-olefin and the DE-ring enol phosphate and a rapid construction of the C-