1028479-47-1

Basic information

• Product Name: 4-FORMYL-2-METHOXYPHENYLBORONIC ACID
• Synonyms: 4-FORMYL-2-METHOXYPHENYLBORONIC ACID
• CAS NO: 1028479-47-1
• Molecular Formula: C₈H₉BO₄
• Molecular Weight: 179.96566
• Mol File: 1028479-47-1.mol

Chemical Properties

• Melting Point: 152-155 °C
• Boiling Point: 400.7±55.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.37±0.58(Predicted)
• CAS DataBase Reference: 4-FORMYL-2-METHOXYPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FORMYL-2-METHOXYPHENYLBORONIC ACID(1028479-47-1)
• EPA Substance Registry System: 4-FORMYL-2-METHOXYPHENYLBORONIC ACID(1028479-47-1)

Safety Data

• Hazardous Substances Data: 1028479-47-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Formyl-2-methoxyphenylboronic acid is used as a reactant in the identification of GDC-0810, an orally bioavailable selective estrogen receptor degrader. 4-FORMYL-2-METHOXYPHENYLBORONIC ACID demonstrates activity in tamoxifen-resistant breast cancer xenografts, making it a significant contributor to the development of targeted therapies for breast cancer treatment.

InChI:InChI=1S/C8H9BO4/c1-13-8-4-6(5-10)2-3-7(8)9(11)12/h2-5,11-12H,1H3

Upstream product

• 121404-83-9 4-iodo-3-methoxybenzaldehyde 
• 1262422-38-7 2-(4-iodo-3-methoxyphenyl)-1,3-dioxane 
• 95970-08-4 1,4-dibromo-2-methoxybenzene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1637437-96-7 (S)-2-((6-(4-(hydroxymethyl)-2-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-phenylethan-1-ol 
• 1637438-04-0 (S)-4-(4-((2-hydroxy-1-phenylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-3-methoxybenzaldehyde 
• 1637437-71-8 (R)-3-methoxy-4-(4-((1-phenylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzaldehyde 
• 1637438-57-3 (4-(4-(benzylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-3-methoxyphenyl)methanol 
• 1637438-75-5 4-(4-(benzylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-3-methoxybenzaldehyde 
• 121-33-5 vanillin 
• 1262422-39-8 3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 
• 1262422-42-3 C₃₁H₃₀O₆ 
• 1262422-41-2 C₃₉H₄₂O₈ 

Relevant articles and documents

Syntheses of macrocyclic bis(bibenzyl) compounds derived from perrottetin e

Macrocyclic bis(bibenzyl) compounds are natural products from liverworts and are of growing interest due to recent reports on new isolated compounds and on their remarkable biological activities. We report here on a flexible and general approach to the to

One-pot generation of lithium (lithiophenyl)trialkoxyborates from substituted dihalobenzenes (Hal = Br, I) and their derivatization with electrophiles

The simple one-pot approach to synthetically useful phenyltrialkoxyborates bearing lithium at the phenyl ring has been developed starting with 1,3- and 1,4-diiodobenzene, as well as several activated dibromobenzenes and bromoiodobenzenes. The general sequence of transformations involves halogen-lithium exchange by using nBuLi and subsequent boronation with a trialkylborate. The resulting lithium (halophenyl) trialkoxyborates were then subjected to halogen-lithium exchange in situ with a second equivalent of nBuLi to give dianionic lithium (lithiophenyl)trialkoxyborates. Treatment with selected electrophiles afforded substituted arylboronic acids and/or their pinacol esters as final products in moderate-to-good yields. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.