121404-83-9

Basic information

• Product Name: 4-iodo-3-methoxybenzaldehyde
• Synonyms: 4-iodo-3-methoxybenzaldehyde
• CAS NO: 121404-83-9
• Molecular Formula: C₈H₇IO₂
• Molecular Weight: 262.04445
• Mol File: 121404-83-9.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-iodo-3-methoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-iodo-3-methoxybenzaldehyde(121404-83-9)
• EPA Substance Registry System: 4-iodo-3-methoxybenzaldehyde(121404-83-9)

Safety Data

• Hazardous Substances Data: 121404-83-9(Hazardous Substances Data)

Usage

General Description

4-iodo-3-methoxybenzaldehyde is an organic compound with the molecular formula C8H7IO2. It is a pale yellow solid with a strong odor and is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. This chemical is primarily used in the preparation of various organic and medicinal compounds due to its reactivity and ability to undergo different chemical reactions. It is also used in research and development to create new drugs and materials. Additionally, 4-iodo-3-methoxybenzaldehyde is considered to be a potentially hazardous chemical and should be handled with care and proper safety precautions.

Upstream product

• 99-06-9 3-Carboxyphenol 
• 58123-77-6 3-hydroxy-4-iodobenzoic acid 
• 591-31-1 3-methoxy-benzaldehyde 
• 41608-64-4 methyl 3-methoxy-4-aminobenzoate 
• 35387-92-9 methyl 4-iodo-3-methoxybenzoate 
• 135242-71-6 3-hydroxy-4-iodobenzaldehyde 
• 74-88-4 methyl iodide 

Downstream Products

• 1227082-72-5 C₁₇H₂₂ClIO₃ 
• 1817626-54-2 PF-06650833 
• 1427393-40-5 1-chloro-7-methoxyisoquinoline-6-carbonitrile 
• 190786-11-9 3-methoxy-4-((trimethylsilyl)ethynyl)benzaldehyde 
• 910920-85-3 C₂₃H₂₄ClN₃O₄ 
• 910920-84-2 C₂₈H₃₄ClN₃O₅ 
• 910920-83-1 5-chloro-3-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-2-methoxy-phenyl]-3-hydroxy-1,3-dihydro-indol-2-one 
• 1262422-38-7 2-(4-iodo-3-methoxyphenyl)-1,3-dioxane 
• 1262422-42-3 C₃₁H₃₀O₆ 
• 1262422-41-2 C₃₉H₄₂O₈ 
• 1262422-39-8 3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 
• 1028479-47-1 (4-formyl-2-methoxyphenyl) boronic acid 
• 1231192-35-0 4-ethynyl-1-iodo-2-methoxy-benzene 

Relevant articles and documents

RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

Bicyclic-Fused Heteroaryl or Aryl Compounds

Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Mild and selective organocatalytic iodination of activated aromatic compounds

We describe an organocatalytic iodination of activated aromatic compounds using 1,3-diiodo-5,5-dimethylhydantoin (DIH) as the iodine source with thiourea catalysts in acetonitrile. The protocol is applicable to a number of aromatic substrates with significantly different steric and electronic properties. The iodination is generally highly regioselective and provides high yields of isolated products. NMR kinetic investigations conducted in THF-d 8indicate the role of sulfur in the thiourea motif as a nucleophile that is assisted by H-bonding in the key steps of the reaction. Georg Thieme Verlag Stuttgart . New York.