10285-64-0

Upstream product

• 3417-91-2 tyrosine methyl ester hydrochloride 
• 39747-65-4 2-tert-Butoxycarbonylamino-3-hydroxy-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 3850-40-6 N-Boc-DL-serine 
• 60-18-4 L-tyrosine 
• 3262-72-4 (S)-N-(tert-butoxycarbonyl)serine 
• 1080-06-4 L-Tyr-OMe 
• 3417-91-2 L-tyrosine methyl ester HCl 

Downstream Products

• 50903-78-1 N^α-tert-butoxycarbonylseryltyrosine 
• 2791-03-9 N^α-tert-butoxycarbonylseryltyrosylserylmethionine methyl ester 
• 2791-02-8 Boc-Ser-Tyr-Ser-Met-N₂H₃ 
• 2791-02-8 {1-[1-[1-(1-Hydrazinocarbonyl-3-methylsulfanyl-propylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester 
• 2791-03-9 2-{2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-hydroxy-propionylamino}-4-methylsulfanyl-butyric acid methyl ester 
• 50903-78-1 2-(2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid 
• 33515-09-2 gonadotropin releasing hormone 
• 49863-06-1 L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazine 
• 94991-11-4 tert-Butyloxycarbonyl-L-tryptophyl-L-seryl-L-tyrosylglycine Methyl Ester 
• 94991-10-3 L-Seryl-L-tyrosylglycine Methyl Ester Hydrochloride 
• 94991-12-5 L-Tryptophyl-L-seryl-L-tyrosylglycine Methyl Ester Hydrochloride 

Relevant academic research and scientific papers

Tyrosine-Specific Modification via a Dearomatization-Rearomatization Strategy: Access to Azobenzene Functionalized Peptides

Azobenzene functionalized peptides are of great importance in photoresponsive biosystems and photopharmacology. Herein, we report an efficient approach to prepare azobenzene functionalized peptides through late-stage modification of tyrosine-containing peptides using a dearomatization-rearomatization strategy. This approach shows good chemoselectivity and site selectivity as well as sensitive group tolerance to various peptides. This method enriches the postsynthetic modification toolbox of peptides and has great potential to be applied in medicinal chemistry and chemical biology.

Diboronic Acid Anhydride-Catalyzed Direct Peptide Bond Formation Enabled by Hydroxy-Directed Dehydrative Condensation

We report the catalytic direct peptide bond formations via dehydrative condensation of β-hydroxy-α-amino acids, affording the serine, threonine, or β-hydroxyvaline-derived peptides in high to excellent yields with high functional group tolerance, minimum epimerization, and excellent chemoselectivity. The key to the success of these atom-economical transformations is the use of diboronic acid anhydride catalyst for the hydroxy-directed reactions.

USE OF THE SILYLATION REACTION IN SYNTHESIS OF FRAGMENT 1-4 OF THE ACTH SEQUENCE

A new effective method of synthesizing fragment 1-4 of the ACTH sequence ensuring a high overall yield of the desired product is proposed.This result is achieved thanks to the wide use of the silylation reaction in the synthesis, which has permitted a con

Synthesis of Gonadoliberin, a Gonadotropin Releasing Hormone

A simple laboratory synthesis of gonadoliberin was elaborated basing on classical solution methods and using minimal protection of the side-chain functions.In the final step a hexapeptide segment was condensed with the corresponding tetrapeptide and the obtained product was purified by a single step silica gel chromatography.The total efficiency of the whole synthesis was 15percent.

USE OF 2-ALKOXY-1-ALKOXYCARBONYL-1,2-DIHYDROQUINOLINES AS CONDENSING AGENTS IN THE SYNTHESIS OF INTERMEDIATE FRAGMENTS OF THE 1 - 4 SEQUENCE OF ACTH

The use of 2-alkoxy-1-alkoxycarbonyl-1,2-dihydroquinolines as a condensing agent in a number of stages in the synthesis of fragments of the 1 - 4 sequence of ACTH is considered.In a number of cases, these compounds have successfully replaced dicyclohexylc