49863-06-1

Basic information

• Product Name: L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazine
• Synonyms: L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazine
• CAS NO: 49863-06-1
• Molecular Weight: 773.806
• Mol File: 49863-06-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazine(49863-06-1)
• EPA Substance Registry System: L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazine(49863-06-1)

Safety Data

• Hazardous Substances Data: 49863-06-1(Hazardous Substances Data)

Upstream product

• 94991-11-4 tert-Butyloxycarbonyl-L-tryptophyl-L-seryl-L-tyrosylglycine Methyl Ester 
• 94991-10-3 L-Seryl-L-tyrosylglycine Methyl Ester Hydrochloride 
• 94991-12-5 L-Tryptophyl-L-seryl-L-tyrosylglycine Methyl Ester Hydrochloride 
• 15160-31-3 (tert-butyloxycarbonyl)-l-tryptophan p-nitrophenyl ester 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 10285-64-0 N^α-tert-butoxycarbonylseryltyrosine methyl ester 

Downstream Products

• 124998-02-3 L-pyroglutamyl-L-histydyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolylglycylglycine acetate 
• 33515-09-2 gonadotropin releasing hormone 

Relevant articles and documents

Synthesis of Gonadoliberin, a Gonadotropin Releasing Hormone

A simple laboratory synthesis of gonadoliberin was elaborated basing on classical solution methods and using minimal protection of the side-chain functions.In the final step a hexapeptide segment was condensed with the corresponding tetrapeptide and the obtained product was purified by a single step silica gel chromatography.The total efficiency of the whole synthesis was 15percent.

Luteinizing hormone releasing hormone and analogs. Synthesis and biological activity

A fragment synthesis of LH RH is described which lends itself to large scale preparation. Fragment 1-3 is coupled with fragment 4-6 followed by reaction with the tetrapeptide 7-10 to yield the unprotected decapeptide. The preparation of analogs follows the same synthetic pattern. The biological activity of the analogs is compared with that of synthetic LH RH.