49863-06-1

Upstream product

• 94991-11-4 tert-Butyloxycarbonyl-L-tryptophyl-L-seryl-L-tyrosylglycine Methyl Ester 
• 94991-10-3 L-Seryl-L-tyrosylglycine Methyl Ester Hydrochloride 
• 94991-12-5 L-Tryptophyl-L-seryl-L-tyrosylglycine Methyl Ester Hydrochloride 
• 15160-31-3 (tert-butyloxycarbonyl)-l-tryptophan p-nitrophenyl ester 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 10285-64-0 N^α-tert-butoxycarbonylseryltyrosine methyl ester 

Downstream Products

• 124998-02-3 L-pyroglutamyl-L-histydyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolylglycylglycine acetate 
• 33515-09-2 gonadotropin releasing hormone 

Relevant academic research and scientific papers

Synthesis of Gonadoliberin, a Gonadotropin Releasing Hormone

A simple laboratory synthesis of gonadoliberin was elaborated basing on classical solution methods and using minimal protection of the side-chain functions.In the final step a hexapeptide segment was condensed with the corresponding tetrapeptide and the obtained product was purified by a single step silica gel chromatography.The total efficiency of the whole synthesis was 15percent.

Process for preparing the releasing hormone of luteinizing hormone (LH) and of follicle stimulating hormone (FSH), salts and compositions thereof, and intermediates therefor

A process for preparing the LH- and FSH-releasing hormone of the formula I which is isolated as the hydrochloride salt and optionally converted to other pharmaceutically acceptable salts or to pharmaceutically acceptable metal complexes.

Luteinizing hormone releasing hormone and analogs. Synthesis and biological activity

A fragment synthesis of LH RH is described which lends itself to large scale preparation. Fragment 1-3 is coupled with fragment 4-6 followed by reaction with the tetrapeptide 7-10 to yield the unprotected decapeptide. The preparation of analogs follows the same synthetic pattern. The biological activity of the analogs is compared with that of synthetic LH RH.