102852-56-2

Usage

General Description

5-hydrazino-isoquinoline dihydrochloride is a chemical compound that is used in the field of biochemistry and pharmaceutical research. It is a hydrazine derivative of isoquinoline, a heterocyclic compound that has potential biological and pharmacological activities. 5-hydrazino-isoquinoline dihydrochloride has been studied for its potential as a substrate in the assay of certain enzymes, as well as its potential as a pharmaceutical agent for the treatment of various diseases. Its unique chemical structure and properties make it a valuable tool for researchers studying biological processes and developing new therapeutic agents.

Upstream product

• 1125-60-6 isoquinolin-5-ylamine 
• 90564-61-7 5-hydrazino-isoquinoline 

Downstream Products

• 102852-57-3 4-methoxycyclohexanone 5-isoquinolylhydrazone 
• 1639450-72-8 C₂₃H₂₂N₄O 
• 1639450-71-7 C₂₃H₂₂N₄O₂ 
• 1639450-79-5 2-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)-3,3-dimethyl-3H-pyrrolo[2,3-f]isoquinoline 
• 1639450-78-4 2-(1-(3-chlorophenyl)-1H-pyrazol-4-yl)-3,3-dimethyl-3H-pyrrolo[2,3-f]isoquinoline 
• 1639450-77-3 2-(1-(4-methoxyphenyl)-1H-pyrazol-4-yl)-3,3-dimethyl-3H-pyrrolo[2,3-f]isoquinoline 
• 1639450-75-1 3,3-dimethyl-2-(1-phenyl-1H-pyrazol-4-yl)-3H-pyrrolo[2,3-f]isoquinoline 
• 91255-37-7 3-(4-Nitrophenylazo)-1H-Pyrrolo<2,3-f>isoquinoline 

Relevant academic research and scientific papers

Synthesis of new heterocyclic compounds using 2-(3,3-dimethyl-1H- pyrroloisoquinolin-2(3H)-ylidene)malonaldehydes

Isoquinolin-5-ylhydrazinium chloride 13 and 5-bromoisoquinolin-8- ylhydrazinium chloride 14 were converted via Fischer syntheses with 3-methylbutan-2-one into indolenines, 2,3,3-trimethyl-3H-pyrrolo[2,3-f] isoquinoline 15 and 5-bromo-2,3,3-trimethyl-3H-pyrrolo[3,2-h]isoquinoline 16, respectively. Exposure of the indolenines to the Vilsmeier reagent produced diformyl compounds 17 and 18, which reacted with arylhydrazines to give the corresponding pyrazoles 19a, 19b, 19c, 19d, 19e, 19f, 19g, 19h, 19i and 20a, 20b, 20c, 20d, 20e, 20f, 20g. Reaction of 17 with thiourea gave a pyrimidine-2(1H)-thione 23 or with hydroxylamine hydrochloride, an isoxazole 24.

Structure-activity relationship studies on N′-aryl carbohydrazide P2X7 antagonists

N′-Aryl acyl hydrazides were identified as P2X7 receptor antagonists. Structure-activity relationship (SAR) studies evaluated functional activity by monitoring calcium flux inhibition in cell lines expressing recombinant human and rat P2X7 receptors. Selected analogs were assayed in vitro for their capacity to inhibit release of cytokine IL-1β. Compounds with potent antagonist function were evaluated in vivo using the zymosan-induced peritonitis model. A representative compound effectively attenuated mechanical allodynia in a rat model of neuropathic pain.

ACYLHYDRAZIDE P2X7 ANTAGONISTS AND USES THEREOF

The present invention discloses a compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein D, A, m, n, Rx and Ry are defined in the description. The present invention also relates to pharmaceutical compositions of compound