1028559-82-1Relevant articles and documents
Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities
Lin, Chien-Hung,Chang, Tsung-Che,Das, Anindya,Fang, Ming-Yu,Hung, Hui-Chen,Hsu, Kai-Cheng,Yang, Jinn-Moon,Von Itzstein, Mark,Mong, Kwok Kong T.,Hsu, Tsu-An,Lin, Chun-Cheng
, p. 3943 - 3948 (2013/07/05)
A series of acylguanidine-modified zanamivir analogs were synthesized and their inhibitory activities against the NAs of avian influenza viruses (H1N1 and H3N2) were evaluated. In particular, zanamivir derivative 3j, with a hydrophobic naphthalene substituent, exhibits the best inhibitory activity against group-1 NA with an IC50 of 20 nM. The Royal Society of Chemistry 2013.