1028570-01-5Relevant academic research and scientific papers
A highly specific BODIPY-based fluorescent probe for the detection of hypochlorous acid
Sun, Zhen-Ning,Liu, Feng-Qin,Chen, Yan,Tam, Paul Kwong Hang,Yang, Dan
supporting information; experimental part, p. 2171 - 2174 (2009/06/18)
(Chemical Equation Presented) A fluorescent probe, HKOCl-1, has been successfully developed for the detection of hypochlorous acid on the basis of a specific reaction with p-methoxyphenol. The formation of HOCl has been successfully detected not only in an abiotic system but also in an enzymatic system (myeloperoxidase/H2O2/Cl- system) and in living macrophage cells upon stimulation. This new probe might be used as an efficient tool for probing the roles HOCl plays in biological systems.
REAGENTS FOR DETECTION OF HYPOCHLOROUS ACID
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Page/Page column 33, (2008/12/07)
Provided herein are compounds or hypochlorous acid probes which can be used as reagents for measuring, detecting and/or screening, directly or indirectly, hypochlorous acid or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of hypochlorous acid or hypochlorite in chemical samples and biological samples such as cells and tissues in living organisms. Specifically, the methods include the steps of contacting the hypochlorous acid probes disclosed herein with the samples to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening hypochlorous acid or compounds that can increase or decrease, directly or indirectly, the level of hypochlorous acid or hypochlorite in chemical and biological samples.
