1028662-86-3Relevant academic research and scientific papers
Development of novel antiatherogenic biaryls: Design, synthesis, and reactivity
Delomenède, Mélanie,Bedos-Belval, Florence,Duran, Hubert,Vindis, Cécile,Baltas, Michel,Nègre-Salvayre, Anne
experimental part, p. 3171 - 3181 (2009/04/11)
On the basis of the 5,5′-bisvanillin scaffold, a series of compounds has been synthesized presenting symmetric or dissymmetric frames on each phenolic moiety. These frames are α,β-unsaturated (fluoro)phosphonate and/or α,β-unsaturated hydrazone(s) formed by coupling aldehydic with isoniazid or hydralazine. All compounds were tested for their ability to inhibit cell-mediated low-density lipoprotein oxidation. Oxidized low-density lipoprotein induced cytotoxicity was also evaluated along with the carbonyl scavenger properties of selected compounds. The most efficient agents were found to be those possessing at least one hydralazinone frame, with the most potent being the symmetrical compound: 4,4′-dihydroxy-3,3′-dimethoxy-5, 5′-biphenyl-1,1′-(diphthalazin-1-yl)methylhydrazone hydrochloride.
Design, synthesis, and evaluation of pharmacological properties of cinnamic derivatives as antiatherogenic agents
Lapeyre, Caroline,Delomenède, Mélanie,Bedos-Belval, Florence,Duran, Hubert,Nègre-Salvayre, Anne,Baltas, Michel
, p. 8115 - 8124 (2007/10/03)
A series of cinnamic and phosphonocinnamic derivatives have been synthesized and their ability to inhibit cell-mediated LDL oxidation and oxidized LDL-induced cytotoxicity was investigated. Electron-donating substituents surrounding the necessary 4-OH gro
Synthesis of phosphonocinnamic thioesters, substrate analogues of cinnamoyl-CoA reductase, a key enzyme in the lignification process
Lapeyre, Caroline,Bedos-Belval, Florence,Duran, Hubert,Baltas, Michel,Gorrichon, Liliane
, p. 2445 - 2447 (2007/10/03)
The one-pot transesterification of diethylarylvinylphosphonates with N-acetylcysteamine has been achieved using phosphonochloridates as intermediates. Reaction of phosphonodiesters with (COCl)2 gave the corresponding chlorinated compounds, whic
