102878-19-3Relevant academic research and scientific papers
Regioselective synthesis of 2-chloroquinoline based ethyl 4-(3-hydroxyphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates and their In-Silico evaluation against P. Falciparum lactate dehydrogenase
Rajesh, Kancherla,Lavanya, Pandian,Iniyavan, Pethaperumal,Sarveswari, Sundaramoorthy,Ramaiah, Sudha,Anbarasu, Anand,Vijayakumar, Vijayaparthasarathi
, p. 789 - 797 (2015/12/01)
The reaction of various substituted 2, 4-dichloroquinolines with ethyl 4-(3-hydroxyphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate was carried out in the presence of K2CO3 as a mild and efficient base at controlled temperature leading to novel 2-chloroquinoline based polyhydroquinoline with high regioselectivity. All the synthesized compounds were characterized using IR, NMR, Mass spectral data and then subjected to an in-silico analysis against P. falciparum lactate dehydrogenase.
Regioselective synthesis of novel 2-chloroquinoline derivatives of 1,4-dihydropyridines
Rajesh,Iniyavan,Sarveswari,Vijayakumar
, p. 1851 - 1866 (2014/05/06)
Highly regioselective reaction of some substituted 2,4-dichloroquinolines with symmetrical 1,4-dihydropyridines, leading to novel quinoline derivatives of DHPs, has been achieved in the presence of powdered K2CO 3, as a mild and efficient base, at moderate temperature. All the synthesized compounds were characterized by use of IR, NMR, and mass spectral data.
Ultrasound-promoted synthesis of novel 2-chloroquinolin-4-pyrimidine carboxylate derivatives as potential antibacterial agents
Balaji,Rajesh,Kouser Ali, Shabana,Vijayakumar
, p. 1807 - 1815 (2013/06/05)
Ultrasound-promoted reaction of substituted 2,4-dichloroquinolines (1) with ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5- carboxylate (2) in the presence of K2CO3 as mild base at moderate temperatures leads
Ultrasound-promoted synthesis, biological evaluation and molecular docking of novel 7-(2-chloroquinolin-4-yloxy)-4-methyl-2H-chromen-2-one derivatives
Balaji,Rajesh,Priya,Iniyavan,Siva,Vijayakumar
, p. 3185 - 3192 (2013/07/19)
A series of quinoline-based coumarin derivatives have been synthesized by one pot dehydrochlorination of 2,4-dichloroquinolines (1a-g); 7-hydroxy-4-methyl-2H-chromen-2-one (2) under ultrasonic irradiation method with high regio selectivity. All the synthesized compounds were characterized through spectral data and screened against representative antibacterial and antioxidant activities. Some of the compounds are found to be equipotent or more potent than that of standard drugs. Molecular docking studies show that the binding energy value of the compounds is very less than that of standard chloroquine and amodiaquine drugs.
A convenient synthesis of 8,9,10,11-tetrahydrodibenzo[b,h] [1,6]naphthyridin-6(5H)ones
Arul Prakash,Rajendran
, p. 353 - 358 (2007/10/03)
Substituted 8,9,10,11-tetrahydrodibenzo[b,h][1,6]naphthyridin-6(5H)ones (5) have been synthesized by the condensation of 4-amino-3-formylquinolin-2(1H)ones (4) with cyclohexanone in presence of acetic acid and sulphuric acid. The precusors have been obtained by the animation of 4-chloro-3-formylquinolin-2(1H)ones (3).
2,4-Dihalogenoquinolines. Synthesis, Orientation Effects and 1H and 13C NMR Spectral Studies
Osborne, Alan G.,Buley, Jill M.,Clarke, Helen,Dakin, Rachel C. H.,Price, Paul I.
, p. 2747 - 2756 (2007/10/02)
Isomer ratios for the syntheses of 2,4-dichloroquinolines from meta-substituted and 3,4-disubstituted anilines are reported, a synthesis of 2,4-dibromoquinoline 1b is also described.The structures of certain bromination products 17 and 1f obtained from 4-hydroxy-2-quinolone have been revised.A thorough study of the 1H and 13C NMR spectra of a series of 2,4-dihalogenoquinolines is presented and the effects of the halogen substituents on JCH couplings are highlighted.
