1028969-49-4 Usage
Description
1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride is a potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist, also known as opioid-receptor-like-1 (ORL1) receptor agonist. It is characterized by its high potency as a non-peptide NOP full agonist in vitro and its anxiolytic properties in mice. 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride has the ability to inhibit signaling through the NOP receptor in the mouse brain, indicating that it can penetrate the brain when administered orally. Importantly, it does not affect locomotor activity or memory and does not contribute to ethanol-induced hypnosis.
Uses
Used in Pharmaceutical Industry:
1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride is used as a potent anxiolytic agent for the treatment of anxiety disorders. Its ability to inhibit NOP receptor signaling in the brain without affecting locomotor activity or memory makes it a promising candidate for developing new therapies for anxiety-related conditions.
Used in Neuropharmacology Research:
In the field of neuropharmacology, this compound serves as a valuable research tool for studying the role of NOP receptors in various physiological and pathological processes. Its high potency and selectivity as a NOP full agonist make it suitable for investigating the mechanisms of action and potential therapeutic applications of NOP receptor modulation.
Used in Drug Development:
1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride is utilized in drug development efforts aimed at creating new medications for the treatment of pain and addiction. Its unique properties, such as the ability to penetrate the brain and modulate NOP receptor signaling, offer opportunities for the development of innovative therapeutics with potential benefits in managing pain and addiction-related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 1028969-49-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,8,9,6 and 9 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1028969-49:
(9*1)+(8*0)+(7*2)+(6*8)+(5*9)+(4*6)+(3*9)+(2*4)+(1*9)=184
184 % 10 = 4
So 1028969-49-4 is a valid CAS Registry Number.
1028969-49-4Relevant articles and documents
Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl] -1H-benzimidazole: Design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent
Hayashi, Shigeo,Hirao, Akiko,Imai, Aki,Nakamura, Hiroshi,Murata, Yoshinori,Ohashi, Katsuyo,Nakata, Eriko
experimental part, p. 610 - 625 (2009/12/29)
An endogenous heptadecapeptide, nociceptin/orphanin FQ (N/OFQ), and a G-protein-coupled receptor, N/OFQ peptide (NOP) receptor [or opioid-receptor-like-1 (ORL1) receptor], have been described in terms of its structure, distribution, and pharmacology. Thus
