102897-56-3Relevant academic research and scientific papers
Biological evaluation of bisbenzaldehydes against four Mycobacterium species
Cappoen, Davie,Forge, Delphine,Vercammen, Frank,Mathys, Vanessa,Kiass, Mehdi,Roupie, Virginie,Anthonissen, Roel,Verschaeve, Luc,Vanden Eynde, Jean Jacques,Huygen, Kris
, p. 731 - 738 (2013/07/25)
A series of bisbenzaldehydes and structurally related analogs, conveniently synthesized via microwave-assisted reactions, were evaluated in vitro against drug susceptible and multi-drug resistant Mycobacterium tuberculosis, against virulent Mycobacterium bovis, against Mycobacterium ulcerans and against two Mycobacterium avium subspecies. Among the 33 substances that were tested, compound 12, i.e. 4,4′-[1,12-dodecanediyl(oxy)]bisbenzaldehyde, emerged as the most promising hit. Its activity was further confirmed in an intracellular growth inhibition assay of M. tb in murine J774 A.1 macrophages. None of the compounds showed significant cytotoxicity on human C3A hepatocytes in a neutral red dye uptake assay and no genotoxicity or mutagenicity was observed as demonstrated by a VITOTOX test and confirmed with a comet assay.
Main chain polymers containing banana-shaped mesogens: Synthesis and mesomorphic properties
Choi, E-Joon,Ahn, Jae-Chul,Chien, Liang-Chy,Lee, Chong-Kwang,Zin, Wang-Cheol,Kim, Dae-Cheol,Shin, Sung-Tae
, p. 71 - 78 (2007/10/03)
Twelve azomethine polymers containing a banana-shaped mesogen as a repeating unit have been synthesized by polycondensation, and their mesomorphic properties were studied. The solution viscosities were measured in a 0.16 g/dL solution in H2SOs
Novel Bis as Antitrypanosomal Agents
Turner, William R.,Werbel, Leslie M.
, p. 1728 - 1740 (2007/10/02)
A series of novel 1,1'-(4,1-phenylene)bis was prepared and evaluated for activity against Trypanosoma rhodesiense in mice.The importance of the bis structure and the nature of the spacer between the two phenyl rings for optimal activity have been revealed.The potent parenteral activity of several analogues within this series as well as preliminary indication of oral activity lends encouragement to further development of this structural class.
