1028981-95-4Relevant academic research and scientific papers
Efficient assembly of 1-(1 H-Imidazol-1-yl)-3-methylene-1H-indenes via tandem reaction of (2-(alkynyl)benzylidene)malonates with imidazoles
Qiu, Guanyinsheng,Ding, Qiuping,Gao, Ke,Peng, Yiyuan,Wu, Jie
experimental part, p. 13 - 18 (2011/04/15)
The tandem nucleophilic addition and 5-exo-cyclization of (2-(alkynyl)benzylidene)malonates with imidazole derivatives in the presence of t-BuOK is reported. This reaction proceeds smoothly under mild conditions with high selectivity to afford the corresp
Sc(OTf)3-catalyzed or t-BuOK promoted tandem reaction of 2-(2-(alkynyl)benzylidene)malonate with indole
Gao, Ke,Wu, Jie
supporting information; experimental part, p. 2251 - 2254 (2009/05/26)
(Chemical Equation Presented) Tandem reaction of 2-(2-(alkynyl)benzylidene) malonate with indole was investigated. (Z)-1-Benzylidene-3-(1H-indol-1-yl)-1H- indene-2,2(3H)-dicarboxylate was generated in the presence of t-BuOK at room temperature; whereas 3-((1H-indol-3-yl)(2-(alkynyl)aryl)methyl)-1H-indole was obtained when Sc(OTf)3 was utilized as catalyst at 50°C.
