1028981-53-4

Upstream product

• 536-74-3 phenylacetylene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 59046-72-9 o-(phenylethynyl)benzaldehyde 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 1028981-95-4 dimethyl (Z)-1-benzylidene-3-(1H-imidazol-1-yl)-1H-indene-2,2(3H)-dicarboxylate 
• 1028981-72-7 dimethyl (Z)-1-benzylidene-3-(1H-indol-1-yl)-1H-indene-2,2(3H)-dicarboxylate 
• 1028981-87-4 3,3'-((2-(phenylethynyl)phenyl)methylene)bis(1H-indole) 
• 1028981-76-1 dimethyl (Z)-1-benzylidene-3-(6-methoxy-1H-indol-1-yl)-1H-indene-2,2(3H)-dicarboxylate 
• 1028981-74-9 dimethyl (Z)-1-benzylidene-3-(4-methoxy-1H-indol-1-yl)-1H-indene-2,2(3H)-dicarboxylate 
• 1258790-99-6 (Z)-dimethyl 1-(1H-benzo[d]imidazol-1-yl)-3-benzylidene-1H-indene-2,2(3H)-dicarboxylate 
• 1258791-01-3 (Z)-dimethyl 1-benzylidene-3-(1H-naphtho[2,3-d]imidaz-ol-1-yl)-1H-indene-2,2(3H)-dicarboxylate 
• 1258790-98-5 (Z)-dimethyl 1-benzylidene-3-(4-methyl-1H-imidazol-1-yl)-1H-indene-2,2(3H)-dicarboxylate 
• 1258791-00-2 (Z)-dimethyl 1-benzylidene-3-(5-methyl-1H-benzo[d]imidazol-1-yl)-1H-indene-2,2(3H)-dicarboxylate 

Relevant academic research and scientific papers

Synthesis of substituted 1,2-dihydroisoquinolinesviaNi(ii) and Cu(i)/Ag(i) catalyzed double nucleophilic addition of arylamines toortho-alkynyl donor-acceptor cyclopropanes (o-ADACs)

A concise approach for the synthesis of substituted 1,2-dihydroisoquinolinesviadouble nucleophilic addition of primary arylamines toortho-alkynyl donor-acceptor cyclopropanes (o-ADACs) in the presence of a catalytic Ni(ClO4)2·6H2O and CuI/AgOTf system has been developed. Further applying this protocol, some of the derived malonates were converted into the corresponding monoesters under Krapcho decarboxylation reaction conditions. Thereafter, these esters were transformed into the respective acids and alcohols. In addition, multifunctionalized 4-(2,2,2-trifluoroacetyl) 1,2-dihydroisoquinolines were also obtained with excess TFAA.

Domino hydroarylation-cyclization reaction: One-pot synthesis of indane-fused 3,4-dihydrocoumarins

A tin(II) triflate-catalyzed domino hydroarylation-cyclization reaction has been developed to access a wide-variety of methyleneindane-fused 3,4-hydrocoumarins. A judiciously selected bi-functional Lewis acidic catalyst has been successfully applied to promote two ring-closing events as a single-pot operation.

Sc(OTf)3-catalyzed or t-BuOK promoted tandem reaction of 2-(2-(alkynyl)benzylidene)malonate with indole

(Chemical Equation Presented) Tandem reaction of 2-(2-(alkynyl)benzylidene) malonate with indole was investigated. (Z)-1-Benzylidene-3-(1H-indol-1-yl)-1H- indene-2,2(3H)-dicarboxylate was generated in the presence of t-BuOK at room temperature; whereas 3-((1H-indol-3-yl)(2-(alkynyl)aryl)methyl)-1H-indole was obtained when Sc(OTf)3 was utilized as catalyst at 50°C.